產(chǎn)品概述
TRIM21 (5B9) Mouse Monoclonal Antibody
Mouse Monoclonal Antibody
Mouse
WB
Human
產(chǎn)品性能
Unconjugated
Unmodified
IgG1
Monoclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Affinity Purification
免疫原
TRIM21
SSA; RO52; SSA1; RNF81; Ro/SSA
6737
P19474
產(chǎn)品應(yīng)用
WB: 1:500-1:1000
Calculated MW: 54 kDa; Observed MW: 50 kDa
研究背景
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.
研究領(lǐng)域
Epigenetics and Nuclear Signaling
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