產(chǎn)品概述
JAK2 (7H5) Mouse Monoclonal Antibody
Mouse Monoclonal Antibody
Mouse
IHC-P
Human,Rat,Mouse
產(chǎn)品性能
Unconjugated
Unmodified
IgG1
Monoclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Affinity Purification
免疫原
JAK2
JAK2; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2
3717
O60674
產(chǎn)品應(yīng)用
IHC: 1:50-1:100
-
研究背景
Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2.
研究領(lǐng)域
Cell Biology
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