化合物 SM-164 Hydrochloride,SM-164 Hydrochloride (957135-43-2 free base)

化合物 SM-164 Hydrochloride|T12932|TargetMol

價(jià)格	￥2575	￥3605	￥5135
包裝	2mg	5mg	10mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2025-07-26

QQ交談微信洽談

產(chǎn)品詳情

中文名稱(chēng):化合物 SM-164 Hydrochloride	英文名稱(chēng):SM-164 Hydrochloride (957135-43-2 free base)
品牌: TargetMol	產(chǎn)地: 美國(guó)
保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.	產(chǎn)品類(lèi)別: 抑制劑
貨號(hào): T12932

Product Introduction

Bioactivity

名稱(chēng)	SM-164 Hydrochloride (957135-43-2 free base)
描述	SM-164 Hydrochloride is a cell-permeable Smac mimetic compound. SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains(IC50 value of 1.39 nM) and functions as an extremely potent antagonist of XIAP.
體外活性	SM-164 is a non-peptide, bivalent small-molecule, cell-permeable, which mimics Smac protein for targeting XIAP. SM-164 binds to XIAP containing both BIR domains(IC50 of 1.39 nM), being 300 and 7000-times more potent than its monovalent counterparts and the natural Smac AVPI peptide, respectively. SM-164 concurrently interacts with both BIR domains in XIAP and functions as an ultra-potent antagonist of XIAP in both cell-free functional and cell-based assays. SM-164 targets cellular XIAP and effectively induces apoptosis at concentrations as low as 1 nM in leukemia cancer cells, while having a minimal toxicity to normal human primary cells at 10,000 nM[1]. The binding affinities of SM-164 to XIAP, cIAP-1, and cIAP-2 proteins are determined using fluorescence-polarization based assays. SM-164 has a Ki value of 0.31 nM to cIAP-1 protein containing both BIR2 and BIR3 domains.SM-164 has a Ki value of 0.56 nM to XIAP protein containing both BIR2 and BIR3 domains. SM-164 binds to cIAP-2 BIR3 protein with Ki values of 1.1 nM. Addition of exogenous TNFα can significantly enhance the activity of these Smac mimetics, especially for SM-164, in resistant cancer cell lines such as HCT116 and MDA-MB-453[2].
體內(nèi)活性	In the MDA-MB-231 xenograft model ,SM-164 is highly effective in inhibition of tumor growth and capable of achieving tumor regression . Treatment with SM-164 at 1 mg/kg completely inhibits tumor growth during the treatment. Treatment with SM-164 at 5 mg/kg reduces the tumor volume from 147±54 mm3 at the beginning of the treatment (day 25) to 54±32 mm3 at the end of the treatment (day 36), a reduction of 65%. The strong antitumor activity by SM-164 is long lasting and not transient. SM-164 at 5 mg/kg is statistically more effective than Taxotere at the end of the treatment (P<0.01) or when the tumor size in the control group reaches 750 mm3 (P<0.02)[2].
存儲(chǔ)條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度	H2O : 106 mg/mL (91.55 mM), Sonication is recommended.
關(guān)鍵字	XIAP \| SM164 Hydrochloride (957135432 free base) \| SM164 Hydrochloride \| SM 164 Hydrochloride (957135 43 2 free base) \| SM 164 Hydrochloride \| cIAP-2 \| cIAP-1 \| cIAP \| 957135-43-2 free base \| 957135-43-2
相關(guān)產(chǎn)品	LCL161 \| Acacetin \| Xevinapant \| Birinapant \| 1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one \| Embelin \| ASTX660 \| BV6 \| N-Deshydroxyethyl Dasatinib \| AZD5582 TFA \| Se-Methylselenocysteine \| HM90822

關(guān)鍵字： SM-164 Hydrochloride|TargetMol

公司簡(jiǎn)介

TargetMol Chemicals Inc. 總部位于馬薩諸塞州波士頓，致力于為全球生化領(lǐng)域科學(xué)家的研究提供專(zhuān)業(yè)的產(chǎn)品和服務(wù)。TargetMol?品牌的客戶(hù)群分布于40多個(gè)國(guó)家和地區(qū)，已發(fā)展成為全球知名的化合物庫(kù)和小分子化合物研究供應(yīng)商。 TargetMol?可提供160多種滿(mǎn)足不同需求的化合物庫(kù)，以及多種類(lèi)型的生化試劑產(chǎn)品，包括12000多種抑制劑、16000多種天然產(chǎn)物和各類(lèi)多肽、抗體、生命科學(xué)試劑盒等，此外，我們還建設(shè)有CADD（計(jì)算機(jī)輔助藥物設(shè)計(jì)）研究中心、藥理實(shí)驗(yàn)室、藥化合成平臺(tái)三大技術(shù)中心，全方位滿(mǎn)足客戶(hù)的定制需求。憑借我們優(yōu)質(zhì)的產(chǎn)品和服務(wù)、快速高效的全球供應(yīng)鏈和專(zhuān)業(yè)的技術(shù)支持，我們將有效幫助您縮短研發(fā)周期，取得更成功的結(jié)果。

成立日期	2013-04-18 （13年）	注冊(cè)資本	589.8595萬(wàn)人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營(yíng)行業(yè)	中間體,天然產(chǎn)物,生物化工,化學(xué)試劑,生物技術(shù)服務(wù)	經(jīng)營(yíng)模式	貿(mào)易,工廠(chǎng),試劑,定制,服務(wù)

TargetMol中國(guó)（陶術(shù)生物）

VIP 2年

公司成立：13年
注冊(cè)資本：589.8595萬(wàn)人民幣
企業(yè)類(lèi)型：有限責(zé)任公司(自然人投資或控股)
主營(yíng)產(chǎn)品：抑制劑&激動(dòng)劑，天然產(chǎn)物，重組蛋白，化合物庫(kù)，技術(shù)服務(wù)
公司地址：上海市靜安區(qū)江場(chǎng)三路238號(hào)8樓

進(jìn)入店鋪

詢(xún)盤(pán)

店內(nèi)推薦

化合物 T30786|T30786|TargetMol

￥10600

化合物 MAC glucuronide phenol-linked SN-38|T18538|TargetMol

詢(xún)價(jià)

化合物 UCM-13369|T87591|TargetMol

詢(xún)價(jià)