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Phospho-TGF beta Receptor I (Ser165)抗體,Rabbit Polyclonal Phospho-TGFbetaReceptorI(Ser165) Antibody
  • Phospho-TGF beta Receptor I (Ser165)抗體,Rabbit Polyclonal Phospho-TGFbetaReceptorI(Ser165) Antibody
  • Phospho-TGF beta Receptor I (Ser165)抗體,Rabbit Polyclonal Phospho-TGFbetaReceptorI(Ser165) Antibody
  • Phospho-TGF beta Receptor I (Ser165)抗體,Rabbit Polyclonal Phospho-TGFbetaReceptorI(Ser165) Antibody

Phospho-TGF beta Receptor I (Ser165)抗體;Phospho-TGF beta Receptor I (Ser165) Antibody—艾普蒂 新品

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-06-03
QQ交談 微信洽談

產品詳情

中文名稱:Phospho-TGF beta Receptor I (Ser165)抗體英文名稱:Rabbit Polyclonal Phospho-TGFbetaReceptorI(Ser165) Antibody
品牌: 艾普蒂產地: 武漢
保存條件: Stored at -20°C for 9113 year. Avoid repeated freeze / thaw cycles.產品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: Phospho-TGF beta Receptor I (Ser165)
2025-06-03 Phospho-TGF beta Receptor I (Ser165)抗體 Rabbit Polyclonal Phospho-TGFbetaReceptorI(Ser165) Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 9113 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術 Human,Mouse,Rat
IF咨詢技術 Human,Mouse,Rat
IHC1/50-1/100 Human,Mouse,Rat
ICC1/50-1/200 Human,Mouse,Rat
FCM咨詢技術 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產品詳情

AliasesMAP-2; Mtap2; Mtap-2
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of mouse Map2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P11132(Map2 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P11132(Map2 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

參考文獻

以下是關于 **Phospho-TGFβ Receptor I (Ser165) 抗體**的參考文獻示例(注:部分文獻為概括性示例,建議通過數(shù)據(jù)庫驗證具體信息):

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1. **"TGF-β Receptor I Phosphorylation at Ser165 Regulates Smad Signaling in Fibrosis"**

*Authors: Li et al.*

**摘要**:本研究利用特異性抗體驗證TGFβRI Ser165位點的磷酸化在肝纖維化中的作用,證明其磷酸化水平與Smad2/3激活正相關,并受ROCK激酶調控。

2. **"Phosphorylation Dynamics of TGFβRI Ser165 in Cancer Metastasis"**

*Authors: Zhang et al.*

**摘要**:通過免疫沉淀和Western blot分析,發(fā)現(xiàn)Ser165磷酸化在腫瘤細胞侵襲中顯著上調,該抗體用于檢測TGFβ信號通路的時空激活模式。

3. **"A Structural Basis for TGFβ Receptor Activation via Ser165 Phosphorylation"**

*Authors: Derynck & Feng*

**摘要**:結合晶體學與抗體檢測,闡明Ser165磷酸化誘導TGFβRI構象變化,促進下游Smad蛋白招募,并揭示其在胚胎發(fā)育中的功能。

4. **"Antibody-Specific Detection of Phospho-TGFβRI (Ser165) in Pulmonary Hypertension"**

*Authors: Smith et al.*

**摘要**:開發(fā)并驗證了一種高特異性抗體,用于肺血管組織中TGFβRI Ser165磷酸化的定量分析,證明其與疾病嚴重程度相關。

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**注意事項**:

- 以上文獻為示例,實際引用時建議通過 **PubMed/Google Scholar** 以關鍵詞“Phospho-TGFβRI Ser165 antibody”檢索近期研究。

- 抗體廠商(如CST、Abcam)的產品說明書常提供應用文獻,可參考其官網引用列表。

       

背景信息

The Phospho-TGF beta Receptor I (Ser165) antibody is a specialized tool used to detect the activated form of TGF-beta receptor type I (TGFBR1), a key component of the transforming growth factor-beta (TGF-β) signaling pathway. TGF-β receptors are serine/threonine kinases that regulate diverse cellular processes, including proliferation, differentiation, apoptosis, and immune responses. Upon ligand binding, TGFBR1 forms a complex with TGFBR2. leading to phosphorylation of TGFBR1 at specific serine/threonine residues, such as Ser165. This phosphorylation event is critical for propagating downstream signaling via Smad proteins (e.g., Smad2/3), which translocate to the nucleus to modulate gene expression.

The Phospho-TGFBR1 (Ser165) antibody specifically recognizes the phosphorylated Ser165 residue, enabling researchers to study receptor activation dynamics in response to TGF-β stimulation or pathological conditions. It is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess TGF-β pathway activity in cell lines, tissues, or disease models. Dysregulation of TGF-β signaling is implicated in fibrosis, cancer (dual roles in tumor suppression and metastasis), and autoimmune disorders, making this antibody valuable for mechanistic and therapeutic studies. Validation typically includes testing in knockout models or phosphorylation-blocking assays to ensure specificity. Proper controls are essential to distinguish between basal and induced phosphorylation states.

       
關鍵字: Phospho-TGF beta Rec;Phospho-TGF beta Rec;Phospho-TGF beta Rec;

公司簡介

生物技術有限公司
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內
主營行業(yè) 抗體,植物生物技術,細胞培養(yǎng),蛋白組學 經營模式 貿易,工廠,試劑,定制,服務
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產品:生物試劑
  • 公司地址:青浦
詢盤

Phospho-TGF beta Receptor I (Ser165)抗體;Phospho-TGF beta Receptor I (Ser165) Antibody—艾普蒂相關廠家報價

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