The Phospho-CDK5 (Tyr15) antibody is a specialized tool used to detect the phosphorylation of cyclin-dependent kinase 5 (CDK5) at tyrosine residue 15. CDK5. a member of the CDK family, is unique in its role as a proline-directed serine/threonine kinase that regulates neuronal development, synaptic plasticity, and dopaminergic signaling. Unlike other CDKs, CDK5 is activated by non-cyclin cofactors, primarily p35 and p39. and its dysregulation is implicated in neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s) and cancer. Phosphorylation at Tyr15 is a post-translational modification that may influence CDK5 activity, substrate specificity, or interactions with regulatory proteins. However, the functional significance of this specific phosphorylation site remains less characterized compared to other CDK5 regulatory mechanisms, such as proteolytic cleavage of p35 to p25. The Phospho-CDK5 (Tyr15) antibody enables researchers to study this modification in cellular models, tissue samples, or disease contexts, particularly in understanding how tyrosine phosphorylation events modulate CDK5 signaling pathways. Its applications include Western blotting, immunohistochemistry, and immunofluorescence, aiding in the exploration of CDK5’s role in both physiological processes and pathological states. Validated specificity for phosphorylated Tyr15 ensures accurate detection, distinguishing it from other CDK5 isoforms or phosphorylation sites.