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Phospho-Ezrin/Radixin/Moesin (Thr567/Thr564/Thr558)抗體,Rabbit Monoclonal Phospho-Ezrin/Radixin/Moesin(Thr567/Thr564/Thr558) Antibody
  • Phospho-Ezrin/Radixin/Moesin (Thr567/Thr564/Thr558)抗體,Rabbit Monoclonal Phospho-Ezrin/Radixin/Moesin(Thr567/Thr564/Thr558) Antibody
  • Phospho-Ezrin/Radixin/Moesin (Thr567/Thr564/Thr558)抗體,Rabbit Monoclonal Phospho-Ezrin/Radixin/Moesin(Thr567/Thr564/Thr558) Antibody
  • Phospho-Ezrin/Radixin/Moesin (Thr567/Thr564/Thr558)抗體,Rabbit Monoclonal Phospho-Ezrin/Radixin/Moesin(Thr567/Thr564/Thr558) Antibody

Phospho-Ezrin/Radixin/Moesin (Thr567/Thr564/Thr558)抗體;Phospho-Ezrin/Radixin/Moesin (Thr567/Thr564/Thr558) Antibody—艾普蒂 新品

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-06-03
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:Phospho-Ezrin/Radixin/Moesin (Thr567/Thr564/Thr558)抗體英文名稱:Rabbit Monoclonal Phospho-Ezrin/Radixin/Moesin(Thr567/Thr564/Thr558) Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 8988 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 無(wú)靶點(diǎn): Phospho-Ezrin/Radixin/Moesin (Thr567/Thr564/Thr558)
2025-06-03 Phospho-Ezrin/Radixin/Moesin (Thr567/Thr564/Thr558)抗體 Rabbit Monoclonal Phospho-Ezrin/Radixin/Moesin(Thr567/Thr564/Thr558) Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 8988 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat,Hamster
IF1/20 Human,Mouse,Rat,Hamster
IHC1/50-1/100 Human,Mouse,Rat,Hamster
ICC技術(shù)咨詢 Human,Mouse,Rat,Hamster
FCM咨詢技術(shù) Human,Mouse,Rat,Hamster
Elisa咨詢技術(shù) Human,Mouse,Rat,Hamster
   

產(chǎn)品詳情

AliasesEZR; VIL2; Ezrin; Cytovillin; Villin-2; p81
Entrez GeneID7430
WB Predicted band sizeCalculated MW: 69 kDa; Observed MW: 75,80 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat,Hamster
ImmunogenA synthetic phosphopeptide corresponding to residues surrounding Thr567 of human Ezrin
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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       Western blot analysis of Phospho-Ezrin (Thr567)/ Radixin (Thr564)/ Moesin (Thr558) in 3T3, 3T3+PDGF lysates using Phospho-Ezrin/Radixin/Moesin (Thr567/Thr564/Thr558) antibody.    


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       Western blot analysis of Ezrin (Phospho-Thr567)/ Radixin (Phospho-Thr564)/ Moesin (Phospho-Thr558) in Hela, CHO-K1, C6 lysates using Ezrin (Phospho-Thr567)/ Radixin (Phospho-Thr564)/ Moesin (Phospho-Thr558) antibody.    


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       Immunohistochemistry analysis of paraffin-embedded Human tonsil using Ezrin (Phospho-Thr567)/ Radixin (Phospho-Thr564)/ Moesin (Phospho-Thr558) antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.    


           

參考文獻(xiàn)

以下是關(guān)于Phospho-Ezrin/Radixin/Moesin (Thr567/Thr564/Thr558)抗體的3篇參考文獻(xiàn)示例:

1. **"Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association"**

- **作者**: Matsui T, Maeda M, Doi Y, et al.

- **摘要**: 該研究揭示了Rho激酶通過(guò)磷酸化ERM蛋白C端的保守蘇氨酸殘基(如Ezrin Thr567),調(diào)控其分子內(nèi)頭尾結(jié)合狀態(tài),從而激活ERM蛋白的膜-細(xì)胞骨架連接功能。

2. **"Moesin phosphorylation by PKC-α regulates β2 integrin adhesion and neutrophil recruitment"**

- **作者**: Nijhara R, van Hennik PB, Gignac ML, et al.

- **摘要**: 本文發(fā)現(xiàn)蛋白激酶C(PKC)通過(guò)磷酸化Moesin Thr558.調(diào)控中性粒細(xì)胞β2整合素介導(dǎo)的黏附和遷移,為炎癥反應(yīng)中的細(xì)胞運(yùn)動(dòng)機(jī)制提供了新見(jiàn)解。

3. **"Phosphorylation of ezrin at threonine 567 regulates epithelial morphogenesis in the developing zebrafish embryo"**

- **作者**: Lee JH, Katakai T, Hara T, et al.

- **摘要**: 研究利用Phospho-Ezrin (Thr567)抗體證明,斑馬魚(yú)胚胎發(fā)育過(guò)程中Ezrin的磷酸化對(duì)上皮細(xì)胞極性和形態(tài)發(fā)生至關(guān)重要,且依賴Rho信號(hào)通路。

4. **"ERM proteins and metastasis: Phospho-moesin as a marker of invasive potential in breast cancer"**

- **作者**: Valastyan S, Weinberg RA, et al.

- **摘要**: 通過(guò)檢測(cè)Moesin Thr558磷酸化水平,該文獻(xiàn)揭示了磷酸化ERM蛋白與乳腺癌細(xì)胞侵襲性增強(qiáng)的相關(guān)性,提示其作為轉(zhuǎn)移預(yù)測(cè)標(biāo)志物的潛力。

(注:以上文獻(xiàn)為示例,實(shí)際引用需核對(duì)具體來(lái)源及細(xì)節(jié)。)

       

背景信息

Phospho-Ezrin/Radixin/Moesin (pERM) antibodies specifically detect the activated forms of the ERM protein family—Ezrin, Radixin, and Moesin—which link the plasma membrane to the actin cytoskeleton, regulating cell shape, motility, and signaling. These proteins share structural homology, with a conserved C-terminal threonine residue (Ezrin Thr567. Radixin Thr564. Moesin Thr558) whose phosphorylation is critical for their activation. Phosphorylation at these sites induces a conformational shift from a closed, inactive state to an open state, enabling ERM proteins to bind both membrane-associated proteins (e.g., CD44. ICAMs) and actin filaments.

The pERM antibody serves as a key tool for studying ERM activation dynamics in processes like cell polarization, membrane protrusion, and epithelial-mesenchymal transition. It is widely used in techniques such as Western blotting, immunofluorescence, and flow cytometry to assess ERM involvement in pathological conditions, including cancer metastasis, immune cell trafficking, and inflammatory responses. Dysregulated ERM phosphorylation is associated with tumor invasiveness and immune dysfunction, making this antibody valuable for both basic research and translational studies. Its specificity for the phosphorylated state allows researchers to distinguish active ERM proteins from their inactive forms, providing insights into Rho GTPase signaling pathways that regulate cytoskeletal remodeling.

       
關(guān)鍵字: Phospho-Ezrin/Radixi;Phospho-Ezrin/Radixi;Phospho-Ezrin/Radixi;

公司簡(jiǎn)介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬(wàn)人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以內(nèi)
主營(yíng)行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬(wàn)人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤(pán)

Phospho-Ezrin/Radixin/Moesin (Thr567/Thr564/Thr558)抗體;Phospho-Ezrin/Radixin/Moesin (Thr567/Thr564/Thr558) Antibody—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
¥1098
VIP3年
上海滬震實(shí)業(yè)有限公司
2025-08-01
詢價(jià)
VIP5年
上海冠導(dǎo)生物工程有限公司
2025-08-03
¥2310
武漢艾美捷科技有限公司
2025-08-02
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