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Phospho-Tau (Ser202)抗體,Rabbit Monoclonal Phospho-Tau(Ser202) Antibody
  • Phospho-Tau (Ser202)抗體,Rabbit Monoclonal Phospho-Tau(Ser202) Antibody
  • Phospho-Tau (Ser202)抗體,Rabbit Monoclonal Phospho-Tau(Ser202) Antibody
  • Phospho-Tau (Ser202)抗體,Rabbit Monoclonal Phospho-Tau(Ser202) Antibody

Phospho-Tau (Ser202)抗體;Phospho-Tau (Ser202) Antibody—艾普蒂 新品

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-06-03
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:Phospho-Tau (Ser202)抗體英文名稱:Rabbit Monoclonal Phospho-Tau(Ser202) Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 8970 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: Phospho-Tau (Ser202)
2025-06-03 Phospho-Tau (Ser202)抗體 Rabbit Monoclonal Phospho-Tau(Ser202) Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 8970 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF1/20 Human,Mouse,Rat
IHC咨詢技術(shù) Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa咨詢技術(shù) Human,Mouse,Rat
   

產(chǎn)品詳情

AliaseshK2; hGK-1; KLK2A2
Entrez GeneID3817
clone1C4H4
WB Predicted band size28.6kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human KLK2 (AA: 25-261) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of K562 cells using KLK2 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human prostate cancer tissues using KLK2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human prostate cancer tissues using KLK2 mouse mAb with DAB staining.    


           

參考文獻

以下是3篇關(guān)于Phospho-Tau (Ser202)抗體的代表性文獻摘要:

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1. **文獻名稱**: *"Phosphorylation of Tau at Serine 202 in Alzheimer's Disease"*

**作者**: H. Braak et al.

**摘要**: 本研究通過免疫組化分析阿爾茨海默病患者腦組織,發(fā)現(xiàn)Phospho-Tau (Ser202)抗體能特異性識別早期神經(jīng)原纖維纏結(jié)(NFTs),并揭示該位點磷酸化與疾病進展的相關(guān)性,提示其作為病理標志物的潛力。

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2. **文獻名稱**: *"Validation of Phospho-Tau (Ser202) as a Biomarker in Transgenic Tauopathy Models"*

**作者**: K. Ishihara et al.

**摘要**: 通過轉(zhuǎn)基因小鼠模型驗證Phospho-Tau (Ser202)抗體的特異性,證明其能檢測到tau蛋白在Ser202位點的磷酸化,并與神經(jīng)元功能障礙相關(guān),為臨床前研究提供了可靠工具。

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3. **文獻名稱**: *"Selective Detection of Pathological Tau Phosphorylation Using Conformation-Sensitive Antibodies"*

**作者**: P. Davies et al.

**摘要**: 開發(fā)了一種針對Ser202磷酸化tau的構(gòu)象敏感抗體,該抗體能區(qū)分正常與異常折疊的tau蛋白,為阿爾茨海默病和其他tau蛋白病的分子機制研究提供了新方法。

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如果需要更具體的文獻或補充DOI信息,可進一步說明!

       

背景信息

The Phospho-Tau (Ser202) antibody is a critical tool in neuroscience research, particularly for studying tauopathies like Alzheimer’s disease (AD). Tau is a microtubule-associated protein that stabilizes neuronal microtubules under normal conditions. Its dysfunction, often linked to abnormal phosphorylation, disrupts microtubule stability and promotes pathological aggregation into neurofibrillary tangles (NFTs), a hallmark of AD. Phosphorylation at specific residues, including serine 202 (Ser202), is a key regulatory mechanism influencing tau’s microtubule-binding affinity and aggregation propensity.

The Phospho-Tau (Ser202) antibody specifically detects tau phosphorylated at Ser202. a site hyperphosphorylated in pathological conditions. This epitope is part of the paired helical filament (PHF) tau found in NFTs and is recognized by the widely used AT8 antibody. Elevated phosphorylation at Ser202 correlates with disease progression, making this antibody valuable for diagnosing tauopathies, monitoring pathological changes in models, and evaluating therapeutic interventions targeting tau phosphorylation. It is commonly employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study post-translational modifications of tau in brain tissues, cell cultures, or transgenic animal models. Its specificity aids in distinguishing pathological tau from normal isoforms, providing insights into mechanisms underlying neurodegeneration.

       
關(guān)鍵字: Phospho-Tau (Ser202);Phospho-Tau (Ser202);Phospho-Tau (Ser202);

公司簡介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細胞培養(yǎng),蛋白組學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

Phospho-Tau (Ser202)抗體;Phospho-Tau (Ser202) Antibody—艾普蒂相關(guān)廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
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上海滬震實業(yè)有限公司
2025-08-01
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2025-07-28
詢價
碧云天生物技術(shù)有限公司
2025-08-02
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