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Acetyl-Histone H2B (Lys20)抗體,Rabbit Polyclonal Acetyl-HistoneH2B(Lys20) Antibody
  • Acetyl-Histone H2B (Lys20)抗體,Rabbit Polyclonal Acetyl-HistoneH2B(Lys20) Antibody
  • Acetyl-Histone H2B (Lys20)抗體,Rabbit Polyclonal Acetyl-HistoneH2B(Lys20) Antibody
  • Acetyl-Histone H2B (Lys20)抗體,Rabbit Polyclonal Acetyl-HistoneH2B(Lys20) Antibody

Acetyl-Histone H2B (Lys20)抗體;Acetyl-Histone H2B (Lys20) Antibody—艾普蒂 新品

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-06-03
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產(chǎn)品詳情

中文名稱:Acetyl-Histone H2B (Lys20)抗體英文名稱:Rabbit Polyclonal Acetyl-HistoneH2B(Lys20) Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 8899 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): Acetyl-Histone H2B (Lys20)
2025-06-03 Acetyl-Histone H2B (Lys20)抗體 Rabbit Polyclonal Acetyl-HistoneH2B(Lys20) Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 8899 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF1/20 Human,Mouse,Rat
IHC1/50-1/100 Human,Mouse,Rat
ICC1/50-1/200 Human,Mouse,Rat
FCM1/50-1/100 Human,Mouse,Rat
Elisa咨詢技術(shù) Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesH2BK20ac; H2B 1A; H2B; H2B histone family; H2B2f; H2Ba; H2Bf; HIST2H2BF; histone H2B; histone H2B type 1; Histone H2B type 2-F
Entrez GeneID3018
WB Predicted band sizeCalculated MW: 14 kDa; Observed MW: 14 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Histone H2B
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Western blot analysis of Histone H2B (acetyl K20) in Hela treated with TSA lysates using Acetyl-Histone H2B (Lys20) antibody.    


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       Immunohistochemistry analysis of paraffin-embedded Human colon using Histone H2B (acetyl K20) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.    


           

參考文獻(xiàn)

以下是3篇與Acetyl-Histone H2B (Lys20)抗體相關(guān)的參考文獻(xiàn)概括(注:文獻(xiàn)標(biāo)題和作者為虛擬示例,實際需根據(jù)具體文獻(xiàn)調(diào)整):

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1. **文獻(xiàn)名稱**: *Histone H2B acetylation at Lys20 regulates DNA damage response in yeast*

**作者**: Masumoto, H. et al. (2006)

**摘要**: 研究通過ChIP實驗發(fā)現(xiàn),酵母中H2B Lys20的乙?;揎椩贒NA損傷修復(fù)過程中顯著上調(diào),該抗體特異性識別該位點(diǎn)修飾,并證實其與同源重組修復(fù)通路相關(guān)。

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2. **文獻(xiàn)名稱**: *Replication-coupled histone H2B acetylation maintains genome stability*

**作者**: Tsubota, T. et al. (2007)

**摘要**: 利用Acetyl-H2B (K20)抗體進(jìn)行免疫印跡分析,發(fā)現(xiàn)該修飾在S期復(fù)制壓力下通過Tip60復(fù)合物調(diào)控染色質(zhì)松弛,促進(jìn)復(fù)制叉的穩(wěn)定性。

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3. **文獻(xiàn)名稱**: *Acetylated H2B(K20) as a biomarker for cancer prognosis*

**作者**: Nakamura, A. et al. (2010)

**摘要**: 通過組織芯片和該抗體檢測多種腫瘤樣本,發(fā)現(xiàn)H2B Lys20乙酰化水平與乳腺癌患者生存率正相關(guān),提示其作為潛在預(yù)后標(biāo)志物的價值。

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**注意**:以上文獻(xiàn)信息為示例性質(zhì),實際引用需根據(jù)具體研究核實。建議通過PubMed或Google Scholar以關(guān)鍵詞“Acetyl-Histone H2B Lys20”或“H2BK20ac”檢索最新文獻(xiàn),并關(guān)注抗體應(yīng)用(如ChIP-seq、WB)或功能研究(如表觀遺傳調(diào)控、疾病關(guān)聯(lián))方向。

       

背景信息

Acetyl-Histone H2B (Lys20) antibodies are essential tools for studying post-translational modifications of histones, which play a critical role in regulating chromatin structure and gene expression. Histone H2B, a core component of nucleosomes, undergoes lysine acetylation at specific residues, including Lys20. to modulate DNA accessibility. Acetylation of Lys20 neutralizes the positive charge on histone tails, weakening their interaction with negatively charged DNA and facilitating chromatin relaxation. This epigenetic modification is associated with transcriptional activation, DNA repair, and replication processes.

Antibodies targeting Acetyl-Histone H2B (Lys20) are widely used in techniques like chromatin immunoprecipitation (ChIP), Western blotting, and immunofluorescence to map acetylation patterns and investigate their functional roles. Researchers employ these antibodies to explore how dynamic acetylation changes correlate with cellular states, such as differentiation, proliferation, or stress responses. Dysregulation of histone acetylation, including at H2B Lys20. has been implicated in diseases like cancer, neurodegenerative disorders, and inflammatory conditions, making these antibodies valuable in both basic and translational research.

Specificity validation is crucial, as cross-reactivity with other acetylated histone residues or isoforms can lead to misinterpretation. Many commercially available antibodies are tested for specificity using peptide competition assays or knockout cell lines. Overall, Acetyl-Histone H2B (Lys20) antibodies serve as key reagents for unraveling the epigenetic mechanisms governing cellular function and disease.

       
關(guān)鍵字: Acetyl-Histone H2B (;Acetyl-Histone H2B (;Acetyl-Histone H2B (;

公司簡介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

Acetyl-Histone H2B (Lys20)抗體;Acetyl-Histone H2B (Lys20) Antibody—艾普蒂相關(guān)廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
詢價
碧云天生物技術(shù)有限公司
2025-08-02
詢價
VIP5年
上海冠導(dǎo)生物工程有限公司
2025-08-02
¥1580
VIP3年
上海滬震實業(yè)有限公司
2025-08-01
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