+ +

•  

   

     Western blot analysis of N4BP1 expression in PC12 cell lysate.    

  
  

**Background of N4BP1 Antibody**

N4BP1 (NEDD4-binding protein 1) is an evolutionarily conserved protein implicated in regulating immune responses, antiviral defense, and cellular signaling pathways. It interacts with NEDD4. an E3 ubiquitin ligase, to modulate ubiquitination-dependent processes such as protein degradation, receptor trafficking, and immune regulation. Structurally, N4BP1 contains a PB1 domain for protein interactions and a ubiquitin-associated (UBA) domain, suggesting roles in ubiquitin signaling.

Studies highlight N4BP1's involvement in limiting excessive inflammation by suppressing NF-κB and type I interferon pathways, making it a critical checkpoint in antiviral immunity. Dysregulation of N4BP1 has been linked to autoimmune disorders and cancer, with evidence showing its tumor-suppressive role in certain contexts.

N4BP1 antibodies are essential tools for detecting the protein’s expression, localization, and interactions in research. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study its function in immune regulation, viral infection responses, and cancer biology. These antibodies (often rabbit or mouse-derived) enable insights into N4BP1's molecular mechanisms and therapeutic potential, though clinical applications remain exploratory.