價(jià)格 | 詢價(jià) | ||
包裝 | 20μl | 50μl | 100μl |
最小起訂量 | 1μl |
發(fā)貨地 | 上海 |
更新日期 | 2025-05-30 |
中文名稱:GCDFP15抗體 | 英文名稱:Rabbit Monoclonal GCDFP15 Antibody |
品牌: 艾普蒂 | 產(chǎn)地: 武漢 |
保存條件: Stored at -20°C for 8713 year. Avoid repeated freeze / thaw cycles. | 產(chǎn)品類別: 抗體 |
重組: 否 | 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA |
種屬反應(yīng)性: Human,Mouse,Rat | 宿主: Rabbit |
偶聯(lián)物: 無 | 靶點(diǎn): GCDFP15 |
WB | 咨詢技術(shù) | Human,Mouse,Rat |
IF | 1/20-1/50 | Human,Mouse,Rat |
IHC | 咨詢技術(shù) | Human,Mouse,Rat |
ICC | 1/50-1/200 | Human,Mouse,Rat |
FCM | 咨詢技術(shù) | Human,Mouse,Rat |
Elisa | 咨詢技術(shù) | Human,Mouse,Rat |
Aliases | BRST2; GCDGP15; gp17; GPIP4; PIP; Prolactin induced protein; SABP; Secretory actin binding protein;;GCDFP 15 |
WB Predicted band size | 17 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | A synthesized peptide derived from human GCDFP 15 |
Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
+ +
Western blot analysis of GCDFP 15 expression in T47D cell lysate.
以下是關(guān)于GCDFP15抗體的3篇參考文獻(xiàn)摘要:
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1. **文獻(xiàn)名稱**: *"GCDFP-15 as a specific marker for breast and salivary gland carcinoma in cytology"*
**作者**: Bhargava R, Beriwal S, Dabbs DJ
**摘要**: 該研究評(píng)估GCDFP15抗體在細(xì)胞學(xué)標(biāo)本中診斷乳腺癌和唾液腺癌的應(yīng)用,證實(shí)其高特異性(尤其在區(qū)分乳腺與其他來源轉(zhuǎn)移癌中的作用),但敏感性受腫瘤異質(zhì)性限制。
2. **文獻(xiàn)名稱**: *"Comparison of GATA3 and GCDFP15 expression in triple-negative breast carcinomas"*
**作者**: Cimino-Mathews A, Subhawong AP, Illei PB
**摘要**: 研究比較GATA3與GCDFP15在三陰性乳腺癌中的表達(dá),發(fā)現(xiàn)GATA3敏感性更高(60% vs. 23%),而GCDFP15特異性更強(qiáng),建議聯(lián)合使用以提高診斷準(zhǔn)確性。
3. **文獻(xiàn)名稱**: *"Utility of GCDFP15 immunohistochemistry in identifying primary sites of metastatic carcinoma"*
**作者**: Lewis GH, Subhawong AP, Nassar H
**摘要**: 分析GCDFP15在轉(zhuǎn)移性癌中的診斷價(jià)值,發(fā)現(xiàn)其對(duì)乳腺和汗腺來源的腫瘤高度特異,但在低分化癌中表達(dá)率低,需結(jié)合其他標(biāo)記物(如ER、HER2)綜合判斷。
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這些研究均強(qiáng)調(diào)GCDFP15抗體的高特異性,但提示其敏感性有限,需與其他標(biāo)記物聯(lián)合使用以提高診斷效能。
GCDFP15 (Gross Cystic Disease Fluid Protein 15), also known as BRST-2 or prolactin-inducible protein (PIP), is a 15 kDa glycoprotein primarily expressed in apocrine secretory cells of the breast, salivary glands, sweat glands, and prostate. It functions in lubrication, immune modulation, and steroid hormone binding. As a tumor marker, GCDFP15 is highly specific for mammary origin, making it a valuable target in diagnostic pathology. The GCDFP15 antibody is a monoclonal or polyclonal reagent used to detect this protein in tissue samples via immunohistochemistry (IHC).
In clinical practice, GCDFP15 antibody aids in identifying primary or metastatic breast carcinomas, particularly hormone receptor-positive and HER2-negative subtypes. It helps differentiate breast cancer metastases from other adenocarcinomas (e.g., lung, ovarian) and confirms apocrine differentiation in breast lesions. While its sensitivity is moderate (~50–70% in breast cancers), its high specificity (>90%) complements other markers like GATA3. Limitations include reduced expression in triple-negative or high-grade tumors and occasional cross-reactivity with salivary or skin adnexal tissues. Recent studies also explore its role in prognostication and therapy response. Overall, GCDFP15 antibody remains a cornerstone in diagnostic algorithms for tumors of uncertain origin.
成立日期 | 2024-07-02 (2年) | 注冊(cè)資本 | 20萬人民幣 |
員工人數(shù) | 1-10人 | 年?duì)I業(yè)額 | ¥ 100萬以內(nèi) |
主營行業(yè) | 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) | 經(jīng)營模式 | 貿(mào)易,工廠,試劑,定制,服務(wù) |
產(chǎn)品名稱 | 價(jià)格 | 公司名稱 | 報(bào)價(jià)日期 | |
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詢價(jià) |
VIP3年
|
維百奧(北京)生物科技有限公司
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2025-08-01 | |
¥1800 |
VIP1年
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費(fèi)雪(杭州)醫(yī)學(xué)研究有限公司
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2025-07-28 | |
詢價(jià) |
上海華盈生物醫(yī)藥科技有限公司
|
2025-08-02 |