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MAD3抗體,Rabbit Monoclonal MAD3 Antibody
  • MAD3抗體,Rabbit Monoclonal MAD3 Antibody
  • MAD3抗體,Rabbit Monoclonal MAD3 Antibody
  • MAD3抗體,Rabbit Monoclonal MAD3 Antibody

MAD3抗體;MAD3 Antibody—艾普蒂 新品

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-30
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:MAD3抗體英文名稱:Rabbit Monoclonal MAD3 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 8709 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: MAD3
2025-05-30 MAD3抗體 Rabbit Monoclonal MAD3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 8709 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/100-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM1/20-1/100 Human,Mouse,Rat
Elisa咨詢技術(shù) Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesbHLHc13; mxd3; Myx;;MAD3
WB Predicted band sizeCalculated MW: 23 kDa ; Observed MW: 28 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human MAD3
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       Western blot analysis of MAD3 expression in HeLa cell lysate.    


           

參考文獻(xiàn)

以下是關(guān)于MAD3抗體的3篇參考文獻(xiàn),按研究內(nèi)容和抗體應(yīng)用整理:

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1. **文獻(xiàn)名稱**: *The Mad2 spindle checkpoint protein has two distinct natively folded states*

**作者**: Fang, G., Yu, H., & Kirschner, M.W.

**摘要**: 該研究通過免疫沉淀和Western blot分析,揭示了MAD2蛋白在紡錘體檢查點中的構(gòu)象變化。研究使用MAD3抗體驗證了MAD2與MAD3(BUBR1)的相互作用,證明兩者共同調(diào)控APC/C的活性,確保染色體正確分離。

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2. **文獻(xiàn)名稱**: *Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1. BUB3. CDC20. and MAD2*

**作者**: Sudakin, V., Chan, G.K., & Yen, T.J.

**摘要**: 通過免疫共沉淀和抗體阻斷實驗,該研究鑒定了由MAD3(BUBR1)、BUB3、CDC20和MAD2組成的紡錘體檢查點復(fù)合物。MAD3抗體被用于特異性識別復(fù)合物組分,并證實其在延緩APC/C活化中的關(guān)鍵作用。

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3. **文獻(xiàn)名稱**: *BUBR1 deficiency results in accelerated mammary tumorigenesis via impaired mitotic checkpoint*

**作者**: Taylor, S.S., Hussein, D., & Wang, Y.

**摘要**: 本研究利用MAD3/BUBR1特異性抗體,通過免疫組織化學(xué)和Western blot分析,發(fā)現(xiàn)BUBR1缺失導(dǎo)致小鼠乳腺腫瘤易感性增加。結(jié)果強調(diào)了MAD3在維持有絲分裂檢查點及基因組穩(wěn)定性中的功能。

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**備注**:MAD3常被稱為BUBR1(BUB1-related kinase),上述文獻(xiàn)中使用的抗體多針對其蛋白表達(dá)及相互作用研究,涉及技術(shù)包括Western blot、免疫沉淀等。如需更近期研究,建議檢索PubMed等數(shù)據(jù)庫以獲取最新進(jìn)展。

       

背景信息

MAD3 (Mitotic Arrest Deficient 3) antibody is primarily associated with the detection of BubR1. a critical protein involved in the spindle assembly checkpoint (SAC) during mitosis. BubR1. encoded by the *BUB1B* gene, ensures accurate chromosome segregation by delaying anaphase until all chromosomes are properly attached to spindle microtubules. Dysfunction in BubR1 is linked to chromosomal instability, a hallmark of cancer, and has been implicated in aging-related disorders.

The MAD3 antibody recognizes BubR1. enabling researchers to study its expression, localization, and interactions in cell cycle regulation. It is widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate SAC mechanisms, mitotic errors, and cellular responses to anti-mitotic drugs. Studies using MAD3 antibodies have revealed BubR1's role in aging, as reduced levels correlate with age-related phenotypes in model organisms. Additionally, its involvement in cancer progression makes it a potential biomarker or therapeutic target.

Originally identified in yeast, the term "MAD3" is sometimes used interchangeably with BubR1 in vertebrates, though nomenclature varies. Researchers employ MAD3 antibodies to explore molecular pathways governing genomic stability, providing insights into diseases like aneuploidy-driven cancers and developmental disorders. Its utility spans basic cell biology, translational oncology, and aging research.

       
關(guān)鍵字: MAD3抗體;MAD3;MAD3 Antibody;

公司簡介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

MAD3抗體;MAD3 Antibody—艾普蒂相關(guān)廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
詢價
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費雪(杭州)醫(yī)學(xué)研究有限公司
2025-07-28
詢價
上海華盈生物醫(yī)藥科技有限公司
2025-08-02
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