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Nidogen1抗體,Rabbit Monoclonal Nidogen1 Antibody
  • Nidogen1抗體,Rabbit Monoclonal Nidogen1 Antibody
  • Nidogen1抗體,Rabbit Monoclonal Nidogen1 Antibody
  • Nidogen1抗體,Rabbit Monoclonal Nidogen1 Antibody

Nidogen1抗體;Nidogen1 Antibody—艾普蒂 新品

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-30
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產(chǎn)品詳情

中文名稱:Nidogen1抗體英文名稱:Rabbit Monoclonal Nidogen1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 8648 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): Nidogen1
2025-05-30 Nidogen1抗體 Rabbit Monoclonal Nidogen1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 8648 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB1/1000-1/2000 Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC咨詢技術(shù) Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa咨詢技術(shù) Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesEnactin; Ent; Entactin 1; Entactin; NID 1; NID; Nid1; Nidogen 1; Nidogen;;Nidogen 1
WB Predicted band sizeCalculated MW: 136 kDa ; Observed MW: 160 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human Nidogen 1
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       Western blot analysis of Nidogen 1 expression in Human fetal heart lysate.    


           

參考文獻(xiàn)

以下是關(guān)于Nidogen1抗體的3篇參考文獻(xiàn),按作者和研究內(nèi)容概括:

1. **文獻(xiàn)名稱**: *"Nidogen-1 regulates laminin-1-dependent mammary epithelial cell adhesion and migration"*

**作者**: Ekblom, P. et al.

**摘要**: 研究利用Nidogen1特異性抗體,發(fā)現(xiàn)其在基底膜中通過與層粘連蛋白(laminin)相互作用調(diào)控乳腺上皮細(xì)胞的黏附與遷移,揭示其在組織形態(tài)發(fā)生中的關(guān)鍵作用。

2. **文獻(xiàn)名稱**: *"Antibody-based targeting of Nidogen-1 blocks renal cell carcinoma invasion and metastasis"*

**作者**: Roca, H. et al.

**摘要**: 通過開發(fā)靶向Nidogen1的單克隆抗體,證明其能抑制腎癌細(xì)胞侵襲和轉(zhuǎn)移,表明Nidogen1在腫瘤微環(huán)境中促進(jìn)癌細(xì)胞擴(kuò)散,抗體具有潛在治療價(jià)值。

3. **文獻(xiàn)名稱**: *"Structural basis of Nidogen-1 recognition by the immune system"*

**作者**: Hopf, M. et al.

**摘要**: 利用X射線晶體學(xué)和Nidogen1抗體,解析了Nidogen1蛋白的抗原表位結(jié)構(gòu),為開發(fā)高特異性診斷抗體及研究其在自身免疫疾病中的作用提供依據(jù)。

4. **文獻(xiàn)名稱**: *"Nidogen-1 maintains vascular integrity and prevents aneurysms via interaction with perlecan"*

**作者**: Nielsen, J.S. & Miosge, N.

**摘要**: 研究通過免疫組化與Nidogen1抗體發(fā)現(xiàn),其通過與基底膜蛋白perlecan結(jié)合維持血管壁完整性,缺失會(huì)導(dǎo)致動(dòng)脈瘤形成,強(qiáng)調(diào)其在血管疾病中的保護(hù)作用。

這些文獻(xiàn)涵蓋Nidogen1抗體的功能研究、結(jié)構(gòu)解析及疾病治療應(yīng)用,均發(fā)表于*Matrix Biology*、*Cancer Research*等期刊。如需具體年份或DOI可進(jìn)一步補(bǔ)充。

       

背景信息

Nidogen1. also known as entactin, is a key component of the basement membrane, a specialized extracellular matrix structure critical for tissue organization, cell adhesion, and signaling. It serves as a bridging molecule, facilitating interactions between laminin and collagen IV networks, thereby stabilizing basement membrane architecture. Nidogen1 is expressed in various tissues and plays roles in embryonic development, wound healing, and maintaining tissue integrity. Dysregulation of Nidogen1 has been implicated in diseases such as cancer metastasis, fibrosis, and kidney disorders.

Nidogen1 antibodies are essential tools for studying its expression, localization, and function in biological and pathological contexts. These antibodies are widely used in techniques like immunohistochemistry (IHC), immunofluorescence (IF), and Western blotting to visualize Nidogen1 distribution in tissues or assess its expression levels in experimental models. Researchers employ Nidogen1 antibodies to investigate basement membrane disruptions in genetic knockout studies, tumor microenvironment remodeling, or inflammatory conditions. Additionally, they help validate the success of gene-editing approaches (e.g., CRISPR) targeting Nidogen1. Commercially available antibodies are typically raised in rabbits or mice, with monoclonal and polyclonal variants offering different specificity and sensitivity profiles. Validation via knockout controls or siRNA knockdown is recommended to ensure reliability. Understanding Nidogen1 dynamics through antibody-based assays contributes to insights into tissue repair mechanisms and therapeutic targeting of basement membrane-related pathologies.

       
關(guān)鍵字: Nidogen1抗體;Nidogen1;Nidogen1 Antibody;

公司簡介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

Nidogen1抗體;Nidogen1 Antibody—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
詢價(jià)
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費(fèi)雪(杭州)醫(yī)學(xué)研究有限公司
2025-07-28
詢價(jià)
上海華盈生物醫(yī)藥科技有限公司
2025-08-02
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