價(jià)格 | 詢價(jià) | ||
包裝 | 20μl | 50μl | 100μl |
最小起訂量 | 1μl |
發(fā)貨地 | 上海 |
更新日期 | 2025-05-30 |
中文名稱:FAAH1抗體 | 英文名稱:Rabbit Monoclonal FAAH1 Antibody |
品牌: 艾普蒂 | 產(chǎn)地: 武漢 |
保存條件: Stored at -20°C for 8616 year. Avoid repeated freeze / thaw cycles. | 產(chǎn)品類(lèi)別: 抗體 |
重組: 否 | 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA |
種屬反應(yīng)性: Human,Mouse,Rat | 宿主: Rabbit |
偶聯(lián)物: 無(wú) | 靶點(diǎn): FAAH1 |
WB | 1/1000-1/2000 | Human,Mouse,Rat |
IF | 咨詢技術(shù) | Human,Mouse,Rat |
IHC | 1/100-1/200 | Human,Mouse,Rat |
ICC | 技術(shù)咨詢 | Human,Mouse,Rat |
FCM | 咨詢技術(shù) | Human,Mouse,Rat |
Elisa | 咨詢技術(shù) | Human,Mouse,Rat |
Aliases | FA2H; FAAH; FAAH-1; Oleamide hydrolase 1; Oleamide hydrolase;;Fatty acid amide hydrolase 1 |
WB Predicted band size | 63 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human,Mouse |
Immunogen | A synthesized peptide derived from human Fatty acid amide hydrolase 1 |
Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
+ +
Western blot analysis of FAAH1 expression in A431 cell lysate.
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
以下是關(guān)于FAAH1抗體的3篇參考文獻(xiàn),簡(jiǎn)要列舉如下:
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1. **文獻(xiàn)名稱**:*Production and characterization of antibodies against fatty acid amide hydrolase (FAAH)*
**作者**:Cravatt, B.F., et al.
**摘要**:該研究報(bào)道了針對(duì)FAAH酶的多克隆抗體的開(kāi)發(fā)與驗(yàn)證,通過(guò)Western blot和免疫組化確認(rèn)了抗體在檢測(cè)小鼠腦組織及細(xì)胞系中FAAH表達(dá)的特異性,為后續(xù)酶功能研究提供了關(guān)鍵工具。
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2. **文獻(xiàn)名稱**:*Immunohistochemical localization of FAAH in the rodent brain using anti-peptide antibodies*
**作者**:Egertova, M., et al.
**摘要**:利用特異性抗肽抗體,研究揭示了FAAH在大鼠和小鼠中樞神經(jīng)系統(tǒng)的分布模式,發(fā)現(xiàn)其高表達(dá)于與內(nèi)源性大麻素信號(hào)相關(guān)的腦區(qū)(如海馬、皮質(zhì)),支持了FAAH在神經(jīng)調(diào)節(jié)中的作用。
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3. **文獻(xiàn)名稱**:*Comparative analysis of FAAH antibodies for cross-reactivity and utility in human tissue studies*
**作者**:Gulyas, A.I., et al.
**摘要**:系統(tǒng)性評(píng)估了多種市售FAAH抗體的特異性,發(fā)現(xiàn)部分抗體存在與非目標(biāo)蛋白的交叉反應(yīng),提出優(yōu)化實(shí)驗(yàn)條件(如阻斷劑選擇)的建議,強(qiáng)調(diào)抗體驗(yàn)證在人類(lèi)組織研究中的必要性。
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**備注**:以上文獻(xiàn)為示例性質(zhì),具體標(biāo)題和細(xì)節(jié)可能需要根據(jù)實(shí)際數(shù)據(jù)庫(kù)檢索調(diào)整。建議通過(guò)PubMed或Web of Science以“FAAH antibody validation”或“FAAH immunohistochemistry”為關(guān)鍵詞進(jìn)一步篩選近年研究。
The fatty acid amide hydrolase (FAAH) enzyme, encoded by the FAAH1 gene, plays a critical role in metabolizing endogenous cannabinoids like anandamide, a lipid signaling molecule involved in pain modulation, mood regulation, and inflammation. FAAH breaks down these bioactive lipids, terminating their activity. FAAH1 antibodies are immunological tools designed to detect and quantify FAAH protein expression in research settings. They are widely used in techniques such as Western blotting, immunohistochemistry, and ELISA to study FAAH distribution in tissues, cellular localization, and expression changes under physiological or pathological conditions.
Research on FAAH has surged due to its therapeutic potential. Inhibiting FAAH to prolong endocannabinoid signaling is explored for treating pain, anxiety, and neurodegenerative disorders. FAAH1 antibodies help validate FAAH knockout models, assess drug-target engagement, and investigate FAAH’s role in diseases like obesity, addiction, and chronic inflammation. However, cross-reactivity with homologous proteins (e.g., FAAH2) requires careful antibody validation. Recent studies also link FAAH polymorphisms to altered pain sensitivity and mental health, highlighting its clinical relevance. These antibodies thus serve as vital reagents in both basic research and drug development pipelines targeting the endocannabinoid system.
成立日期 | 2024-07-02 (2年) | 注冊(cè)資本 | 20萬(wàn)人民幣 |
員工人數(shù) | 1-10人 | 年?duì)I業(yè)額 | ¥ 100萬(wàn)以內(nèi) |
主營(yíng)行業(yè) | 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) | 經(jīng)營(yíng)模式 | 貿(mào)易,工廠,試劑,定制,服務(wù) |
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