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DNAPolymerasegamma抗體,Rabbit Monoclonal DNAPolymerasegamma Antibody
  • DNAPolymerasegamma抗體,Rabbit Monoclonal DNAPolymerasegamma Antibody
  • DNAPolymerasegamma抗體,Rabbit Monoclonal DNAPolymerasegamma Antibody
  • DNAPolymerasegamma抗體,Rabbit Monoclonal DNAPolymerasegamma Antibody

DNAPolymerasegamma抗體;DNAPolymerasegamma Antibody—艾普蒂 新品

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-30
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:DNAPolymerasegamma抗體英文名稱:Rabbit Monoclonal DNAPolymerasegamma Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 8607 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: DNAPolymerasegamma
2025-05-30 DNAPolymerasegamma抗體 Rabbit Monoclonal DNAPolymerasegamma Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 8607 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB1/1000-1/2000 Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC咨詢技術(shù) Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa咨詢技術(shù) Human,Mouse,Rat
   

產(chǎn)品詳情

Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human GABRB1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12574(GABRB1 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12574(GABRB1 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是3-4條關(guān)于DNA Polymerase gamma(POLG)抗體的參考文獻(xiàn)示例,包含文獻(xiàn)名稱、作者及簡要摘要內(nèi)容:

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1. **文獻(xiàn)名稱**: "Autoantibodies against DNA polymerase gamma in patients with paraneoplastic neurological syndromes"

**作者**: Engelsen, B. et al.

**摘要**: 該研究探討了副腫瘤性神經(jīng)綜合征(PNS)患者血清中抗POLG抗體的存在及其臨床意義,發(fā)現(xiàn)此類抗體可能與神經(jīng)退行性變和線粒體功能障礙相關(guān)。

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2. **文獻(xiàn)名稱**: "POLG autoantibodies: A novel biomarker in mitochondrial disorders"

**作者**: Hadjivassiliou, M. et al.

**摘要**: 提出抗POLG抗體可作為線粒體疾病的潛在生物標(biāo)志物,研究通過ELISA檢測患者血清抗體水平,發(fā)現(xiàn)其與POLG基因突變導(dǎo)致的線粒體腦肌病相關(guān)。

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3. **文獻(xiàn)名稱**: "Detection of anti-DNA polymerase gamma antibodies in primary biliary cirrhosis"

**作者**: Westermann, C. et al.

**摘要**: 研究檢測了原發(fā)性膽汁性膽管炎(PBC)患者中抗POLG抗體的頻率,提示其可能參與自身免疫性肝病的病理機制,并與線粒體損傷有關(guān)。

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4. **文獻(xiàn)名稱**: "Antibody profiling in mitochondrial encephalomyopathy: Insights into POLG-associated autoimmunity"

**作者**: Lee, H. & DiMauro, S.

**摘要**: 分析線粒體腦肌病患者中的自身抗體譜,發(fā)現(xiàn)抗POLG抗體與POLG基因突變患者的神經(jīng)系統(tǒng)癥狀嚴(yán)重程度呈正相關(guān),可能影響疾病進(jìn)展。

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**注意**:以上文獻(xiàn)為示例性內(nèi)容,實際引用時需核實具體文獻(xiàn)信息及準(zhǔn)確性。建議通過PubMed、Google Scholar等平臺以關(guān)鍵詞“POLG antibody”或“anti-DNA polymerase gamma”檢索最新研究。

       

背景信息

DNA polymerase gamma (Pol γ) antibody is a crucial tool in studying mitochondrial DNA (mtDNA) replication and repair. Pol γ, encoded by the *POLG* gene, is the sole DNA polymerase responsible for replicating and repairing mtDNA in eukaryotic cells. It consists of a catalytic subunit (Pol γA) and an accessory subunit (Pol γB), which together ensure high-fidelity synthesis of mtDNA. Mutations in *POLG* are linked to mitochondrial disorders such as Kearns-Sayre syndrome, Alpers syndrome, and progressive external ophthalmoplegia, highlighting its essential role in mitochondrial function.

Antibodies targeting Pol γ are typically generated using recombinant proteins or synthetic peptides corresponding to conserved regions of Pol γA or Pol γB. These antibodies enable the detection, quantification, and localization of Pol γ in various tissues and cell types through techniques like Western blotting, immunohistochemistry, and immunofluorescence. They are vital for diagnosing *POLG*-related diseases, assessing protein expression levels in mitochondrial dysfunction studies, and investigating the impact of pathogenic mutations on Pol γ stability or activity.

Additionally, Pol γ antibodies support research into mtDNA maintenance mechanisms, aging, and chemotherapy-induced mitochondrial toxicity. Their specificity is often validated using knockout cell lines or competitive peptide-blocking assays. By facilitating the study of Pol γ's structure-function relationships and its interactions with other mitochondrial proteins, these antibodies contribute to advancing our understanding of mitochondrial biology and associated diseases.

       
關(guān)鍵字: DNAPolymerasegamma抗體;DNAPolymerasegamma;DNAPolymerasegamma A;

公司簡介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

DNAPolymerasegamma抗體;DNAPolymerasegamma Antibody—艾普蒂相關(guān)廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
詢價
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費雪(杭州)醫(yī)學(xué)研究有限公司
2025-07-28
詢價
上海華盈生物醫(yī)藥科技有限公司
2025-08-02
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