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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     Western blot analysis of Syntaxin expression in Human fetal brain lysate.    

  
  

Syntaxin antibodies are essential tools in neuroscience and cell biology research, targeting proteins belonging to the syntaxin family—a subset of SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins critical for membrane fusion events. Syntaxins are transmembrane proteins localized to specific cellular compartments, such as the plasma membrane, synaptic vesicles, or Golgi apparatus, where they mediate vesicle docking and fusion with target membranes. Among the 15+ mammalian isoforms, syntaxin-1A/B is particularly well-studied for its role in neurotransmitter release at neuronal synapses, interacting with partner SNAREs (e.g., SNAP-25 and synaptobrevin) to form the core complex that drives exocytosis.

Syntaxin antibodies are widely used to investigate synaptic function, intracellular trafficking, and membrane dynamics. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to visualize syntaxin expression, localization, and interactions. For example, syntaxin-1 antibodies help map synaptic terminals or study defects in neurotransmitter release models. Other isoforms, like syntaxin-4 (involved in insulin secretion) or syntaxin-17 (autophagy-related), are targeted to explore non-neuronal processes. Dysregulation of syntaxins has been linked to neurological disorders (e.g., epilepsy, Alzheimer’s), endocrine diseases, and cancer, making these antibodies valuable for both basic research and clinical diagnostics. Their specificity and validation (e.g., knockout controls) are critical to ensure accurate interpretation of cellular mechanisms.