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OGT抗體,Rabbit Monoclonal OGT Antibody
  • OGT抗體,Rabbit Monoclonal OGT Antibody
  • OGT抗體,Rabbit Monoclonal OGT Antibody
  • OGT抗體,Rabbit Monoclonal OGT Antibody

OGT抗體;OGT Antibody—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-30
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:OGT抗體英文名稱:Rabbit Monoclonal OGT Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 8376 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: OGT
2025-05-30 OGT抗體 Rabbit Monoclonal OGT Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 8376 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHCIHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC1/50-1/200 Human,Mouse,Rat
FCM1/20-1/100 Human,Mouse,Rat
Elisa咨詢技術(shù) Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesHRNT1; O-GLCNAC;;OGT
WB Predicted band sizeCalculated MW: 117 kDa ; Observed MW: 110 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human OGT
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    


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       All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    


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       Western blot analysis of OGT / O-Linked N-Acetylglucosamine Transferase expression in A549 cell lysate.    


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       Immunofluorescent analysis using the Antibody at 1:50 dilution.    


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       Immunofluorescent analysis using the Antibody at 1:50 dilution.    


           

參考文獻

以下是關(guān)于OGT抗體的3篇文獻示例,涵蓋不同研究方向,供參考:

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**1. 文獻名稱**:*O-GlcNAc Transferase (OGT) Regulates Proteasome Function via Site-Specific Ubiquitination*

**作者**:Wang, Z., et al. (2020)

**摘要**:該研究利用OGT特異性抗體,通過免疫共沉淀(Co-IP)和Western blot技術(shù),揭示了OGT通過調(diào)控蛋白酶體亞基的O-GlcNAc修飾影響其功能。研究發(fā)現(xiàn),抑制OGT活性會降低細胞中泛素化蛋白的降解效率,提示OGT在蛋白質(zhì)穩(wěn)態(tài)中的關(guān)鍵作用。

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**2. 文獻名稱**:*Tissue-Specific OGT Knockout Mice Reveal Neuronal Insulin Resistance and Cognitive Impairment*

**作者**:Liu, Y., et al. (2019)

**摘要**:研究利用OGT抗體進行腦組織免疫組化分析,發(fā)現(xiàn)神經(jīng)元特異性O(shè)GT敲除小鼠出現(xiàn)胰島素信號通路異常及認知功能下降。結(jié)果強調(diào)了OGT介導的糖基化在神經(jīng)代謝疾病中的潛在機制。

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**3. 文獻名稱**:*Development of a High-Affinity Monoclonal Antibody for OGT Detection in Cancer Biomarker Screening*

**作者**:Chen, H., et al. (2021)

**摘要**:該團隊開發(fā)了一種新型OGT單克隆抗體,具有高特異性和敏感性,適用于ELISA和免疫熒光。通過對比多種癌癥組織樣本,發(fā)現(xiàn)OGT表達水平與腫瘤侵襲性呈正相關(guān),為癌癥診斷提供了新工具。

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**注**:以上文獻信息為模擬示例,實際引用時建議通過PubMed或?qū)I(yè)數(shù)據(jù)庫核對原文。如需具體文獻,可提供研究方向(如疾病模型、技術(shù)開發(fā)等),將補充更精準的參考文獻。

       

背景信息

O-GlcNAc transferase (OGT) is an essential enzyme that catalyzes the addition of O-linked β-N-acetylglucosamine (O-GlcNAc) modifications to serine and threonine residues of target proteins. This post-translational modification, termed O-GlcNAcylation, plays a critical role in regulating cellular processes such as nutrient sensing, transcription, stress response, and epigenetic regulation. As a key mediator of the hexosamine biosynthetic pathway, OGT links metabolic flux to cellular signaling by dynamically modifying nuclear, cytoplasmic, and mitochondrial proteins. Dysregulation of OGT activity or O-GlcNAc cycling has been implicated in metabolic disorders, cancer, neurodegenerative diseases, and cardiovascular conditions.

OGT antibodies are indispensable tools for studying the enzyme's expression, localization, and functional interactions. They enable detection of OGT protein levels via Western blotting, immunohistochemistry, or immunofluorescence, and facilitate research into its substrate specificity and regulatory mechanisms. Due to OGT's structural complexity (including multiple isoforms and a tetratricopeptide repeat domain for protein interactions), generating specific antibodies requires careful validation to avoid cross-reactivity. These antibodies have advanced understanding of OGT's dual roles as a nutrient sensor and epigenetic modulator, particularly its interplay with phosphorylation signaling and involvement in insulin resistance, aging, and chromatin remodeling. Recent studies also explore OGT's potential as a therapeutic target, emphasizing the continued importance of high-quality antibodies in both basic and translational research.

       
關(guān)鍵字: OGT抗體;OGT;OGT Antibody;

公司簡介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細胞培養(yǎng),蛋白組學 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

OGT抗體;OGT Antibody—艾普蒂相關(guān)廠家報價

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2025-07-30
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詢價
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