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     Western blot analysis of CXCL11 expression in THP1 cell lysate.    

  
  

CXCL11. a member of the CXC chemokine family, is primarily induced by interferon-gamma (IFN-γ) and plays a critical role in immune cell recruitment, particularly Th1 lymphocytes and natural killer (NK) cells, by binding to its receptors CXCR3 and CXCR7. It is involved in inflammatory responses, tumor immunity, and autoimmune diseases. CXCL11 antibodies are essential tools for detecting and studying this chemokine’s expression, localization, and function in both physiological and pathological contexts.

In research, CXCL11 antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and flow cytometry to analyze protein levels in tissues, serum, or cultured cells. They help elucidate CXCL11's dual role in cancer: promoting antitumor immunity by recruiting effector T cells while potentially supporting tumor angiogenesis and metastasis in certain microenvironments. Additionally, these antibodies are valuable in studying autoimmune conditions like multiple sclerosis and rheumatoid arthritis, where CXCL11 overexpression correlates with disease severity.

Clinically, CXCL11 antibodies have potential diagnostic and therapeutic applications. They may serve as biomarkers for monitoring inflammatory diseases or predicting immunotherapy responses in oncology. Recent studies also explore their use in blocking CXCL11-CXCR3/CXCR7 interactions to modulate immune pathways. As research advances, CXCL11 antibodies remain pivotal in uncovering mechanistic insights and developing targeted therapies for immune-related disorders.