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GPX4抗體,Rabbit Monoclonal GPX4 Antibody
  • GPX4抗體,Rabbit Monoclonal GPX4 Antibody
  • GPX4抗體,Rabbit Monoclonal GPX4 Antibody
  • GPX4抗體,Rabbit Monoclonal GPX4 Antibody

GPX4抗體;GPX4 Antibody—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-29
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:GPX4抗體英文名稱:Rabbit Monoclonal GPX4 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 8133 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: GPX4
2025-05-29 GPX4抗體 Rabbit Monoclonal GPX4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 8133 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHCIHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC1/50-1/200 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa咨詢技術(shù) Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesGPX4; GSHPx-4; MCSP; mitochondrial; PHGPx; Phospholipid hydroperoxidase; snGPx; snPHGPx; Sperm nucleus glutathione peroxidase;;GPX4
WB Predicted band sizeCalculated MW: 22 kDa ; Observed MW: 17 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human GPX4
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    


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       All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    


  •  

     

       All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    


  •  

     

       All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    


  •  

     

       All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    


  •  

     

       All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    


  •  

     

       All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    


  •  

     

       All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    


  •  

     

       All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    


  •  

     

       All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    


           

參考文獻

以下是關(guān)于GPX4抗體的3篇示例文獻(內(nèi)容為模擬概括,僅供參考):

1. **文獻名稱**:*GPX4 regulates ferroptosis and cell death in cancer*

**作者**:Yang WS, Stockwell BR

**摘要**:該研究通過Western blot和免疫組化使用GPX4抗體,證實GPX4通過抑制脂質(zhì)過氧化調(diào)控鐵死亡,其失活可誘導癌細胞死亡,為癌癥治療提供新靶點。

2. **文獻名稱**:*Inactivation of GPX4 triggers ferroptosis in vivo*

**作者**:Conrad M, Friedmann Angeli JP

**摘要**:利用基因敲除模型和GPX4抗體檢測,發(fā)現(xiàn)GPX4缺失會導致小鼠器官中鐵死亡激活,揭示了GPX4在維持細胞氧化穩(wěn)態(tài)中的關(guān)鍵作用。

3. **文獻名稱**:*Characterization of GPX4 antibody specificity in neurodegenerative models*

**作者**:Schneider KS, et al.

**摘要**:研究比較了多種市售GPX4抗體的特異性,驗證了其在腦組織樣本中的適用性,為神經(jīng)退行性疾病中GPX4蛋白表達分析提供了實驗依據(jù)。

(注:以上為示例性內(nèi)容,實際文獻需通過學術(shù)數(shù)據(jù)庫檢索確認。)

       

背景信息

The glutathione peroxidase 4 (GPX4) antibody is a critical tool in studying the role of GPX4. a selenium-containing antioxidant enzyme essential for cellular redox homeostasis. GPX4 uniquely reduces lipid hydroperoxides within membranes, thereby preventing ferroptosis—a form of regulated cell death driven by iron-dependent lipid peroxidation. This enzyme is pivotal in mitigating oxidative damage, particularly in tissues with high metabolic activity, such as the liver, brain, and kidneys. Dysregulation of GPX4 is linked to pathologies including cancer, neurodegenerative diseases, and ischemia-reperfusion injury.

GPX4 antibodies are widely used in research to detect protein expression and localization via techniques like Western blotting, immunohistochemistry, and immunofluorescence. They help elucidate GPX4's involvement in ferroptosis modulation, its interaction with pathways like the glutathione and mevalonate systems, and its role in therapeutic resistance. For instance, cancer studies exploit GPX4 antibodies to explore tumor survival mechanisms, as GPX4 inhibition can sensitize cells to ferroptosis inducers. Similarly, in neurodegenerative research, these antibodies aid in understanding how GPX4 depletion exacerbates lipid peroxidation in conditions like Alzheimer’s disease.

The development of specific, high-affinity GPX4 antibodies remains vital for advancing mechanistic insights and therapeutic strategies targeting ferroptosis-related diseases.

       
關(guān)鍵字: GPX4抗體;GPX4;GPX4 Antibody;

公司簡介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細胞培養(yǎng),蛋白組學 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

GPX4抗體;GPX4 Antibody—艾普蒂相關(guān)廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
詢價
VIP5年
上海冠導生物工程有限公司
2025-08-04
詢價
VIP4年
湖北魏氏化學試劑股份有限公司
2025-07-31
¥1600.00
VIP10年
北京索萊寶科技有限公司
2025-07-30
詢價
湖北艾普蒂生物工程有限公司
2024-02-21
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