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     IHC-P analysis of brain tissue by MGRN1 antibody (P15780). IHC-P was performed using sections of the formalin-fixed paraffin-embedded brain tissue. Result: Neuropil and cytoplasm of neuronal cells are positively stained ;    

  
  

The MGRN1 (Mahogunin Ring Finger 1) antibody is a research tool used to study the MGRN1 protein, an E3 ubiquitin ligase involved in ubiquitination processes that regulate protein degradation, trafficking, and signaling. MGRN1 is encoded by the *MGRN1* gene and plays roles in diverse physiological pathways, including neurodevelopment, melanogenesis, and mitochondrial function. It interacts with proteins such as TSG101 and modulates cellular stress responses. Dysregulation of MGRN1 has been linked to neurodegenerative conditions, as its loss in animal models causes spongiform encephalopathy, ataxia, and premature lethality. Mutations in *MGRN1* are also associated with altered pigmentation in mice and may contribute to human metabolic or neurological disorders.

MGRN1 antibodies are primarily used in Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression, localization, and interactions in tissues or cultured cells. These antibodies help investigate MGRN1’s role in cellular quality control, its association with prion-like pathologies, and its potential involvement in cancer or metabolic syndromes. Commercial MGRN1 antibodies are typically validated for specificity using knockout controls or siRNA-mediated knockdown. Researchers utilize these tools to explore mechanisms underlying neurodegeneration, mitochondrial dysfunction, and ubiquitin-dependent signaling pathways. Despite progress, the full scope of MGRN1’s functions and its therapeutic relevance remain active areas of study.