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     IHC-P analysis of spleen tissue by BLOC1S3 antibody (P15649) IHC-P was performed using sections of the formalin-fixed paraffin-embedded spleen tissue;Result: Cells in white pulp are positively stained at the cytoplasm.    

  
  

The BLOC1S3 antibody is a tool used to detect BLOC1S3. a subunit of the Biogenesis of Lysosome-Related Organelles Complex 1 (BLOC-1), which plays a critical role in intracellular vesicle trafficking and organelle biogenesis. BLOC-1 is an eight-protein complex involved in the formation and function of lysosome-related organelles (LROs), such as melanosomes in pigment cells and platelet dense granules. BLOC1S3. encoded by the BLOC1S3 gene, contributes to the stability and function of the BLOC-1 complex. Defects in BLOC1S3 or other BLOC-1 subunits are linked to Hermansky-Pudlak syndrome (HPS), a rare autosomal recessive disorder characterized by oculocutaneous albinism, bleeding disorders, and, in some cases, lung fibrosis or immunodeficiency.

BLOC1S3 antibodies are widely used in research to study protein expression, localization, and interactions within cellular pathways. They help elucidate molecular mechanisms underlying HPS and other disorders involving LRO dysfunction. These antibodies are validated for applications like Western blotting, immunofluorescence, and immunoprecipitation, enabling researchers to explore BLOC1S3's role in membrane trafficking, cargo sorting, and disease pathogenesis. Their development has advanced understanding of how BLOC-1 dysfunction impacts cellular homeostasis and contributes to multisystemic disorders.