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     Western blot analysis using CMPK2 mouse mAb against  Jurkat lysate    

  
  

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     IHC-P analysis of adrenal gland tissue by CMPK2 antibody (P15295) IHC-P was performed using sections of the formalin-fixed paraffin-embedded adrenal gland tissue;Result: Glandular cells are positively stained at the cytoplasm.    

  
  

CMPK2 (cytidine/uridine monophosphate kinase 2) is a mitochondrial enzyme belonging to the nucleoside monophosphate kinase family, primarily involved in nucleotide metabolism. It catalyzes the phosphorylation of pyrimidine nucleotides (e.g., UMP, CMP) to their diphosphate forms, supporting mitochondrial DNA synthesis and replication. CMPK2 has gained attention for its role in antiviral innate immunity, where it interacts with mitochondrial antiviral-signaling protein (MAVS) to enhance interferon production during RNA viral infections. Dysregulation of CMPK2 is implicated in diseases such as cancer, neurodegenerative disorders, and viral pathogenesis.

CMPK2 antibodies are essential tools for detecting and quantifying CMPK2 protein expression, localization, and interactions in research. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study CMPK2's function in mitochondrial dynamics, antiviral responses, and disease mechanisms. Polyclonal and monoclonal antibodies targeting specific epitopes (e.g., human or mouse CMPK2) are commercially available, with validation often involving knockout cell lines or siRNA-mediated silencing. Recent studies also explore CMPK2's potential as a therapeutic target, particularly in antiviral drug development and cancer immunotherapy. Proper antibody validation remains critical to ensure specificity, given sequence homology with other kinases.