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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13691(KCNT1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The KCNT1 antibody is a research tool designed to detect the KCNT1 protein, a sodium-activated potassium channel subunit encoded by the *KCNT1* gene. This channel, also known as Slack (Sequence Like a Calcium-activated K+ channel), plays a critical role in regulating neuronal excitability by mediating potassium ion flow across cell membranes. KCNT1 is highly expressed in the brain and contributes to action potential repolarization and neurotransmitter release. Mutations in *KCNT1* are linked to severe neurological disorders, including epilepsy of infancy with migrating focal seizures (EIMFS), autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), and developmental encephalopathies. These mutations often cause gain-of-function channel defects, leading to hyperexcitability in neural circuits.

KCNT1 antibodies are primarily used in biomedical research to study protein expression, localization, and functional alterations in disease models. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess KCNT1 levels in tissues or cultured cells. Researchers also utilize these antibodies to explore how pathogenic variants affect channel trafficking or interaction with regulatory proteins. Understanding KCNT1's role in disease mechanisms could aid in developing targeted therapies, such as channel blockers or gene-based interventions. However, commercial KCNT1 antibodies vary in specificity, requiring careful validation to ensure reliable experimental outcomes. Ongoing studies aim to clarify KCNT1's broader physiological roles and its potential as a biomarker or therapeutic target.