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HNRNPAB抗體,Rabbit Polyclonal HNRNPAB Antibody
  • HNRNPAB抗體,Rabbit Polyclonal HNRNPAB Antibody
  • HNRNPAB抗體,Rabbit Polyclonal HNRNPAB Antibody
  • HNRNPAB抗體,Rabbit Polyclonal HNRNPAB Antibody

HNRNPAB抗體;HNRNPAB Antibody—艾普蒂

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-28
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:HNRNPAB抗體英文名稱:Rabbit Polyclonal HNRNPAB Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 7382 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): HNRNPAB
2025-05-28 HNRNPAB抗體 Rabbit Polyclonal HNRNPAB Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 7382 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB1/200-1/1000 Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesABBP1; HNRPAB
WB Predicted band size36 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human HNRNPAB
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Jurkat cell, Human fetal brain tissue lysates, Primary antibody: P13586(HNRNPAB Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P13586(HNRNPAB Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13586(HNRNPAB Antibody) at dilution 1/20. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于HNRNPAB抗體的參考文獻(xiàn)示例(注:內(nèi)容為假設(shè)性示例,實(shí)際文獻(xiàn)需通過學(xué)術(shù)數(shù)據(jù)庫核實(shí)):

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1. **文獻(xiàn)名稱**: "HNRNPAB regulates embryonic neurogenesis via mRNA splicing"

**作者**: Li X, et al.

**摘要**: 本研究利用HNRNPAB特異性抗體,通過免疫共沉淀和RNA-seq技術(shù),揭示了HNRNPAB在斑馬魚胚胎神經(jīng)發(fā)育中通過調(diào)控關(guān)鍵基因(如Notch通路成員)的選擇性剪接發(fā)揮重要作用。

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2. **文獻(xiàn)名稱**: "Overexpression of HNRNPAB promotes hepatocellular carcinoma metastasis"

**作者**: Wang Y, et al.

**摘要**: 通過免疫組化(使用HNRNPAB抗體)和體外實(shí)驗(yàn),作者發(fā)現(xiàn)HNRNPAB在肝癌組織中高表達(dá),并通過穩(wěn)定Snail mRNA促進(jìn)上皮-間質(zhì)轉(zhuǎn)化(EMT),進(jìn)而驅(qū)動(dòng)腫瘤轉(zhuǎn)移。

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3. **文獻(xiàn)名稱**: "HNRNPAB interacts with TDP-43 in ALS-associated RNA granules"

**作者**: Smith J, et al.

**摘要**: 該研究利用HNRNPAB抗體進(jìn)行免疫熒光共定位,證實(shí)HNRNPAB與TDP-43在肌萎縮側(cè)索硬化癥(ALS)患者神經(jīng)元中形成異常RNA-蛋白聚集體,可能參與疾病進(jìn)展。

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4. **文獻(xiàn)名稱**: "Dynamic role of HNRNPAB in DNA damage response"

**作者**: Chen R, et al.

**摘要**: 通過Western blot(使用HNRNPAB抗體)和CRISPR敲除技術(shù),研究發(fā)現(xiàn)HNRNPAB通過結(jié)合ATM激酶mRNA并增強(qiáng)其翻譯,調(diào)控細(xì)胞對(duì)DNA損傷的反應(yīng)。

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如需真實(shí)文獻(xiàn),建議在PubMed或Google Scholar中檢索關(guān)鍵詞:**HNRNPAB antibody** + 研究領(lǐng)域(如cancer, splicing, neurodegeneration)。

       

背景信息

HNRNPAB (heterogeneous nuclear ribonucleoprotein A/B) is a member of the hnRNP family, which comprises RNA-binding proteins involved in various aspects of RNA metabolism, including splicing, transport, stability, and translation. HNRNPAB, also known as HNRPDL or ABBP1. contains RNA recognition motifs (RRMs) that enable interactions with RNA and other proteins. It plays a role in mRNA processing, particularly in regulating alternative splicing and mRNA export from the nucleus to the cytoplasm. Dysregulation of HNRNPAB has been implicated in cancer progression, where its overexpression promotes tumor metastasis, proliferation, and epithelial-mesenchymal transition (EMT) in malignancies such as hepatocellular carcinoma, colorectal cancer, and breast cancer.

Antibodies targeting HNRNPAB are essential tools for studying its molecular functions and pathological roles. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect protein expression levels, subcellular localization, and interactions with RNA or partner proteins. Commercially available HNRNPAB antibodies are typically raised against specific epitopes, such as the N-terminal or C-terminal regions, and validated for specificity across human and other model organisms. In research, these antibodies help elucidate HNRNPAB's involvement in stress granule formation, viral RNA processing, and its potential as a biomarker for cancer prognosis. Understanding HNRNPAB's mechanisms may also inform therapeutic strategies targeting RNA-binding proteins in disease contexts.

       
關(guān)鍵字: HNRNPAB抗體;HNRNPAB;HNRNPAB Antibody;

公司簡(jiǎn)介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

HNRNPAB抗體;HNRNPAB Antibody—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
¥1950
VIP3年
上海滬震實(shí)業(yè)有限公司
2025-08-01
¥960.00
VIP10年
北京索萊寶科技有限公司
2025-07-30
詢價(jià)
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
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