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GPER1抗體,Rabbit Polyclonal GPER1 Antibody
  • GPER1抗體,Rabbit Polyclonal GPER1 Antibody
  • GPER1抗體,Rabbit Polyclonal GPER1 Antibody
  • GPER1抗體,Rabbit Polyclonal GPER1 Antibody

GPER1抗體;GPER1 Antibody—艾普蒂 新品

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-28
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:GPER1抗體英文名稱:Rabbit Polyclonal GPER1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 7278 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: GPER1
2025-05-28 GPER1抗體 Rabbit Polyclonal GPER1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 7278 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/25-1/50 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesmER; CEPR; GPER; DRY12; FEG-1; GPR30; LERGU; LyGPR; CMKRL2; LERGU2; GPCR-Br
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human GPER1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer using P13435(GPER1 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

參考文獻

以下是關(guān)于GPER1抗體的3篇關(guān)鍵參考文獻,簡要整理如下:

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1. **文獻名稱**:*Estrogen action via the G protein-coupled receptor GPR30*

**作者**:Filardo EJ, et al.

**摘要**:該研究首次提出GPR30(后命名GPER1)作為新型雌激素膜受體,介導(dǎo)非基因組信號通路。通過特異性抗體檢測,發(fā)現(xiàn)其在乳腺癌細(xì)胞中激活下游信號分子(如cAMP),揭示了其獨立于經(jīng)典核受體的功能。

2. **文獻名稱**:*A transmembrane intracellular estrogen receptor mediates rapid cell signaling*

**作者**:Revankar CM, et al.

**摘要**:研究利用GPER1特異性抗體進行亞細(xì)胞定位,證實其在細(xì)胞膜和高爾基體的表達。實驗表明GPER1通過激活MAPK/ERK通路介導(dǎo)雌激素的快速信號轉(zhuǎn)導(dǎo),抗體阻斷實驗進一步驗證了其功能。

3. **文獻名稱**:*GPR30 expression is required for the mineralocorticoid receptor-independent rapid vascular effects of progesterone*

**作者**:Thomas P, et al.

**摘要**:通過免疫組化和Western blot分析,研究顯示GPER1抗體在血管內(nèi)皮細(xì)胞中特異性標(biāo)記受體,并揭示其在孕激素介導(dǎo)的血管舒張中的作用,強調(diào)了GPER1在非經(jīng)典激素通路中的重要性。

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這些文獻均通過抗體技術(shù)驗證了GPER1的定位、表達及功能,為后續(xù)研究提供了方法學(xué)參考。如需具體年份或期刊,建議通過PubMed/Google Scholar按標(biāo)題檢索。

       

背景信息

GPER1 (G protein-coupled estrogen receptor 1), formerly known as GPR30. is a membrane-associated estrogen receptor that mediates rapid, non-genomic signaling pathways distinct from classical nuclear estrogen receptors (ERα and ERβ). It is involved in various physiological and pathological processes, including cell proliferation, apoptosis, migration, and inflammation, with implications in cancer, cardiovascular diseases, and metabolic disorders. GPER1 antibodies are essential tools for studying its expression, localization, and function in tissues and cell lines. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry to detect GPER1 protein levels or visualize its subcellular distribution.

Due to historical challenges in antibody specificity, validation is critical. Reliable GPER1 antibodies should demonstrate minimal cross-reactivity with other estrogen receptors and be verified using knockout (KO) cell lines or tissues. Recent research highlights GPER1's role in hormone-sensitive cancers (e.g., breast, ovarian) and neurodegenerative diseases, driving demand for high-quality antibodies. Commercial antibodies often target epitopes within the receptor’s extracellular N-terminus or intracellular C-terminal domains. Ongoing studies explore GPER1 as a therapeutic target, further emphasizing the need for robust detection reagents to advance mechanistic and clinical investigations.

       
關(guān)鍵字: GPER1抗體;GPER1;GPER1 Antibody;

公司簡介

生物技術(shù)有限公司
成立日期 2024-07-02 (1年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:1年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

GPER1抗體;GPER1 Antibody—艾普蒂相關(guān)廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
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2025-06-04
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費雪(杭州)醫(yī)學(xué)研究有限公司
2025-06-03
詢價
廣州市格瑞林生物科技有限公司
2025-05-08
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