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P3H2抗體,Rabbit Polyclonal P3H2 Antibody
  • P3H2抗體,Rabbit Polyclonal P3H2 Antibody
  • P3H2抗體,Rabbit Polyclonal P3H2 Antibody
  • P3H2抗體,Rabbit Polyclonal P3H2 Antibody

P3H2抗體;P3H2 Antibody—艾普蒂 新品

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-28
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:P3H2抗體英文名稱:Rabbit Polyclonal P3H2 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 7235 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): P3H2
2025-05-28 P3H2抗體 Rabbit Polyclonal P3H2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 7235 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesMCVD; MLAT4; LEPREL1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human P3H2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13372(P3H2 Antibody) at dilution 1/35. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于P3H2抗體的3篇參考文獻(xiàn)示例,包含文獻(xiàn)名稱、作者及摘要概括:

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1. **文獻(xiàn)名稱**:*Prolyl 3-hydroxylase 2 (P3H2) deficiency alters collagen cross-linking in osteogenesis imperfecta model*

**作者**:Martinez, A. et al.

**摘要**:本研究利用CRISPR技術(shù)構(gòu)建P3H2敲除小鼠模型,開發(fā)特異性P3H2抗體用于Western blot和免疫熒光分析,發(fā)現(xiàn)P3H2缺失導(dǎo)致膠原Ⅲ羥基化異常,影響骨骼強(qiáng)度。

2. **文獻(xiàn)名稱**:*Antibody-based detection of P3H2 in dermal fibrosis: Implications for scleroderma pathogenesis*

**作者**:Kim, S. & Patel, R.

**摘要**:通過制備兔源多克隆P3H2抗體,研究團(tuán)隊(duì)發(fā)現(xiàn)系統(tǒng)性硬化癥患者皮膚組織中P3H2表達(dá)顯著上調(diào),提示其可能通過調(diào)控膠原穩(wěn)定性參與纖維化進(jìn)程。

3. **文獻(xiàn)名稱**:*Development of a monoclonal antibody targeting P3H2 for diagnostic applications in connective tissue disorders*

**作者**:Gonzalez, L. et al.

**摘要**:報道一種高特異性抗P3H2單克隆抗體的開發(fā),驗(yàn)證其在ELISA和免疫組化中的應(yīng)用,證實(shí)其在馬方綜合征患者成纖維細(xì)胞中P3H2表達(dá)異常,為臨床診斷提供潛在工具。

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注:以上文獻(xiàn)信息為示例,實(shí)際研究中請通過學(xué)術(shù)數(shù)據(jù)庫查詢真實(shí)發(fā)表的論文。

       

背景信息

The P3H2 antibody targets prolyl 3-hydroxylase 2 (P3H2), an enzyme belonging to the prolyl hydroxylase family involved in collagen biosynthesis. P3H2. encoded by the *LEPRE1* gene, catalyzes the post-translational 3-hydroxylation of specific proline residues in collagen chains, a critical modification for collagen folding, stability, and fibrillogenesis. It primarily acts on type I, II, IV, and V collagens, which are essential components of connective tissues, cartilage, and basement membranes.

Research on P3H2 gained momentum due to its association with osteogenesis imperfecta (OI) and other connective tissue disorders. Mutations in *LEPRE1* disrupt collagen hydroxylation, leading to abnormal fibril formation and tissue fragility. Antibodies against P3H2 are pivotal in studying collagen maturation pathways, protein-protein interactions (e.g., with CRTAP and cyclophilin B in the collagen-modifying complex), and disease mechanisms. They enable detection of P3H2 expression in tissues, assessment of its localization, and evaluation of its role in pathological conditions.

Recent studies also explore P3H2's potential in regenerative medicine, particularly in bone and cartilage repair. The antibody serves as a tool to investigate therapeutic strategies targeting collagen modifications, such as small molecule inhibitors or gene therapies. Its development underscores the growing interest in collagen biology and extracellular matrix-related diseases, bridging fundamental research with clinical applications.

       
關(guān)鍵字: P3H2抗體;P3H2;P3H2 Antibody;

公司簡介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

P3H2抗體;P3H2 Antibody—艾普蒂相關(guān)廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
詢價
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費(fèi)雪(杭州)醫(yī)學(xué)研究有限公司
2025-07-28
詢價
上海華盈生物醫(yī)藥科技有限公司
2025-08-02
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