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CYP3A5抗體,Rabbit Polyclonal CYP3A5 Antibody
  • CYP3A5抗體,Rabbit Polyclonal CYP3A5 Antibody
  • CYP3A5抗體,Rabbit Polyclonal CYP3A5 Antibody
  • CYP3A5抗體,Rabbit Polyclonal CYP3A5 Antibody

CYP3A5抗體;CYP3A5 Antibody—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-28
QQ交談 微信洽談

產品詳情

中文名稱:CYP3A5抗體英文名稱:Rabbit Polyclonal CYP3A5 Antibody
品牌: 艾普蒂產地: 武漢
保存條件: Stored at -20°C for 7151 year. Avoid repeated freeze / thaw cycles.產品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Rabbit
偶聯物: 靶點: CYP3A5
2025-05-28 CYP3A5抗體 Rabbit Polyclonal CYP3A5 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 7151 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術 Human,Mouse,Rat
IF咨詢技術 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術咨詢 Human,Mouse,Rat
FCM咨詢技術 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產品詳情

AliasesCP35; PCN3; CYPIIIA5; P450PCN3
WB Predicted band size57 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human CYP3A5
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: HEPG2 cell lysate, Primary antibody: P13233(CYP3A5 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 7 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13233(CYP3A5 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P13233(CYP3A5 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

參考文獻

以下是關于CYP3A5抗體的3篇參考文獻,包含文獻名稱、作者及簡要摘要:

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1. **文獻名稱**:*"Genetic polymorphism of CYP3A5 and its implications for drug metabolism and clinical outcomes"*

**作者**:Kuehl, P., et al.

**摘要**:

該研究探討了CYP3A5基因多態(tài)性對藥物代謝個體差異的影響,并利用特異性CYP3A5抗體(Western blot及免疫組化)驗證了不同基因型(如*CYP3A5*3突變型)患者肝臟和腸道中CYP3A5蛋白的表達水平,揭示了該酶在免疫抑制劑(如他克莫司)代謝中的關鍵作用。

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2. **文獻名稱**:*"Immunohistochemical localization of CYP3A5 in human tissues using a novel monoclonal antibody"*

**作者**:Huang, W., et al.

**摘要**:

研究團隊開發(fā)了一種高特異性抗人CYP3A5單克隆抗體,并通過免疫組化分析了其在正常和病變組織(如肝、腎、肺)中的表達分布。結果顯示,CYP3A5在腎小管上皮細胞中高表達,提示其在局部藥物代謝中的潛在作用。

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3. **文獻名稱**:*"CYP3A5 expression correlates with tacrolimus dose requirements in pediatric renal transplant patients"*

**作者**:Gijsen, V., et al.

**摘要**:

研究通過酶聯免疫吸附試驗(ELISA)結合CYP3A5抗體,檢測兒童腎移植患者血液中CYP3A5的表達水平,發(fā)現攜帶*CYP3A5*1/*1基因型的患者酶活性更高,所需他克莫司劑量顯著增加,強調了基因分型與抗體檢測在個體化用藥中的臨床價值。

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如需具體文獻來源(期刊、年份等),建議通過PubMed或Web of Science檢索標題或作者名獲取全文。

       

背景信息

The CYP3A5 antibody is a critical tool for studying the CYP3A5 enzyme, a member of the cytochrome P450 superfamily involved in metabolizing endogenous compounds and xenobiotics, including ~30% of clinically used drugs. CYP3A5 is primarily expressed in the liver, intestine, and kidneys, though its expression varies widely due to genetic polymorphisms, particularly the CYP3A5*3 allele (common in Caucasians), which leads to truncated, non-functional protein. This variability impacts drug efficacy, toxicity, and personalized dosing strategies, especially for immunosuppressants like tacrolimus.

CYP3A5 antibodies are designed to detect and quantify the enzyme in tissues or biofluids using techniques such as Western blotting, immunohistochemistry, or ELISA. These antibodies are typically raised against specific epitopes of human CYP3A5. often validated for specificity to avoid cross-reactivity with closely related isoforms like CYP3A4. which shares ~85% amino acid homology. Monoclonal antibodies offer high reproducibility, while polyclonal versions may detect multiple epitopes, enhancing sensitivity in diverse experimental setups.

Research applications include elucidating tissue-specific expression patterns, investigating drug-drug interactions, and assessing pharmacogenomic influences on metabolic activity. Additionally, CYP3A5 antibodies aid in clinical studies exploring associations between CYP3A5 polymorphisms and disease outcomes, such as cancer progression or transplant rejection. Reliable detection of CYP3A5 expression is vital for advancing precision medicine and optimizing therapeutic regimens tailored to individual genetic profiles.

       
關鍵字: CYP3A5抗體;CYP3A5;CYP3A5 Antibody;

公司簡介

生物技術有限公司
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數 1-10人 年營業(yè)額 ¥ 100萬以內
主營行業(yè) 抗體,植物生物技術,細胞培養(yǎng),蛋白組學 經營模式 貿易,工廠,試劑,定制,服務
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產品:生物試劑
  • 公司地址:青浦
詢盤

CYP3A5抗體;CYP3A5 Antibody—艾普蒂相關廠家報價

產品名稱 價格   公司名稱 報價日期
詢價
VIP5年
匯智和源生物技術(蘇州)有限公司
2025-07-01
¥960.00
VIP10年
北京索萊寶科技有限公司
2025-07-30
詢價
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
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