+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13212(COX15 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The COX15 antibody is a research tool used to study the COX15 protein, a key component in mitochondrial energy production. COX15. or cytochrome c oxidase assembly protein homolog 15. is essential for the biogenesis of cytochrome c oxidase (Complex IV), the terminal enzyme in the mitochondrial electron transport chain (ETC). It catalyzes the synthesis of heme \(a\), a prosthetic group critical for Complex IV activity. Mutations in the COX15 gene are linked to mitochondrial disorders, such as Leigh syndrome and hypertrophic cardiomyopathy, characterized by impaired cellular energy metabolism.

COX15 antibodies enable the detection and quantification of COX15 protein levels in various experimental models, including cell cultures, tissues, and animal samples. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate COX15 expression, subcellular localization, and interactions. Researchers employ COX15 antibodies to explore mitochondrial dysfunction mechanisms, assess disease biomarkers, and evaluate therapeutic interventions targeting ETC defects. Their specificity and validation are crucial for ensuring accurate results in studies on mitochondrial biology, metabolic diseases, and aging-related pathologies.