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CNGA4抗體,Rabbit Polyclonal CNGA4 Antibody
  • CNGA4抗體,Rabbit Polyclonal CNGA4 Antibody
  • CNGA4抗體,Rabbit Polyclonal CNGA4 Antibody
  • CNGA4抗體,Rabbit Polyclonal CNGA4 Antibody

CNGA4抗體;CNGA4 Antibody—艾普蒂

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-28
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:CNGA4抗體英文名稱:Rabbit Polyclonal CNGA4 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 7129 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): CNGA4
2025-05-28 CNGA4抗體 Rabbit Polyclonal CNGA4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 7129 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesCNG4; CNG5; CNCA2; CNG-4; CNGB2; OCNC2; OCNCb; OCNCBETA
WB Predicted band size66 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human CNGA4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human cerebrum tissue and Human cerebella tissue lysates, Primary antibody: P13201(CNGA4 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13201(CNGA4 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于CNGA4抗體的3篇代表性文獻(xiàn)概覽,涵蓋其功能研究及抗體應(yīng)用:

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1. **文獻(xiàn)名稱**: *Subunit composition of the cyclic nucleotide-gated channel in olfactory sensory neurons*

**作者**: Bradley J, B?nigk W, Yau KW

**摘要**:該研究通過免疫共沉淀和Western blot技術(shù),利用CNGA4特異性抗體,證實(shí)了CNGA4亞基與CNGA2、CNGB1b共同構(gòu)成嗅覺神經(jīng)元中的環(huán)核苷酸門控通道復(fù)合體,揭示了其在通道組裝中的關(guān)鍵作用。

2. **文獻(xiàn)名稱**: *Antibody-based profiling of cyclic nucleotide-gated channel subunits in olfactory epithelium*

**作者**: Zheng J, Trudeau MC

**摘要**:文章開發(fā)了針對(duì)CNGA4等亞基的多克隆抗體,通過免疫組織化學(xué)和蛋白質(zhì)印跡分析,證明了CNGA4在嗅覺纖毛中的特異性表達(dá),并探討其與嗅覺信號(hào)轉(zhuǎn)導(dǎo)功能的相關(guān)性。

3. **文獻(xiàn)名稱**: *Phosphorylation-dependent regulation of CNGA4 channel activity by protein kinase C*

**作者**: Julifs DM, Fülle HJ, Biel M

**摘要**:研究利用CNGA4特異性抗體檢測(cè)其在HEK293細(xì)胞中的表達(dá),發(fā)現(xiàn)PKC介導(dǎo)的磷酸化可調(diào)控CNGA4通道活性,提示其在嗅覺適應(yīng)中的潛在分子機(jī)制。

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**注**:以上文獻(xiàn)為模擬示例,實(shí)際引用時(shí)建議通過PubMed或Web of Science等平臺(tái)檢索最新文獻(xiàn)。若需具體文章,可進(jìn)一步提供數(shù)據(jù)庫查詢協(xié)助。

       

背景信息

The CNGA4 antibody targets the cyclic nucleotide-gated channel alpha-4 (CNGA4), a subunit of the cyclic nucleotide-gated (CNG) ion channel family. CNG channels are non-selective cation channels activated by cyclic nucleotides (cAMP or cGMP) and play critical roles in sensory transduction, particularly in olfactory and photoreceptor cells. CNGA4 is primarily expressed in olfactory sensory neurons, where it forms heterotetrameric channels with CNGA2 and CNGB1b subunits. Unlike other CNG subunits, CNGA4 lacks intrinsic channel activity but modulates channel properties, such as enhancing ligand sensitivity, accelerating channel gating, and regulating calcium-dependent feedback mechanisms essential for odor adaptation.

Antibodies against CNGA4 are valuable tools for studying the structure, function, and localization of these channels in olfactory signaling. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate CNGA4 expression patterns in tissues or cellular models. Research involving CNGA4 antibodies has contributed to understanding congenital anosmia (loss of smell) and neurodegenerative disorders linked to olfactory dysfunction. Additionally, these antibodies aid in exploring channelopathies—diseases caused by ion channel malfunctions—and potential therapeutic targets. Recent studies also highlight CNGA4's role in non-olfactory tissues, suggesting broader physiological implications. Overall, CNGA4 antibodies are pivotal in unraveling the molecular mechanisms of sensory signaling and related pathologies.

       
關(guān)鍵字: CNGA4抗體;CNGA4;CNGA4 Antibody;

公司簡(jiǎn)介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

CNGA4抗體;CNGA4 Antibody—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
¥1800
VIP1年
費(fèi)雪(杭州)醫(yī)學(xué)研究有限公司
2025-08-13
詢價(jià)
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
詢價(jià)
上海華盈生物醫(yī)藥科技有限公司
2025-08-18
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