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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13102(CNTN5 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

CNTN5 (Contactin-5), a member of the immunoglobulin (Ig) superfamily of cell adhesion molecules, plays critical roles in neuronal development, synaptic organization, and neural network formation. It is predominantly expressed in the central and peripheral nervous systems, where it mediates cell-cell interactions through homophilic or heterophilic binding, often partnering with receptor-type tyrosine phosphatases like PTPRG. CNTN5 is implicated in axon guidance, myelination, and plasticity, with emerging links to neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia.

Antibodies targeting CNTN5 are essential tools for investigating its expression, localization, and function in both physiological and pathological contexts. These antibodies are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to map CNTN5 distribution in neural tissues or assess its levels in disease models. Researchers also employ CNTN5 antibodies to study its interactions with binding partners (e.g., amyloid precursor protein (APP)) and its role in signaling pathways.

Recent studies highlight CNTN5's potential as a biomarker or therapeutic target, driving demand for high-specificity antibodies. Commercially available CNTN5 antibodies are typically validated in knockout models or siRNA-mediated knockdown systems to confirm target specificity. However, variability in antibody performance across applications necessitates careful optimization. Ongoing research using these antibodies aims to unravel CNTN5's contributions to neural circuit dysregulation in psychiatric diseases and its broader implications in neurodegenerative conditions.