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URI1抗體,Rabbit Polyclonal URI1 Antibody
  • URI1抗體,Rabbit Polyclonal URI1 Antibody
  • URI1抗體,Rabbit Polyclonal URI1 Antibody
  • URI1抗體,Rabbit Polyclonal URI1 Antibody

URI1抗體;URI1 Antibody—艾普蒂

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-28
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:URI1抗體英文名稱:Rabbit Polyclonal URI1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 6985 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): URI1
2025-05-28 URI1抗體 Rabbit Polyclonal URI1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 6985 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesRMP; URI; NNX3; C19orf2; PPP1R19
WB Predicted band size60 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human URI1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: K562 and 293T cell lysates, Primary antibody: P12987(URI1 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 50 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P12987(URI1 Antibody) at dilution 1/45. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12987(URI1 Antibody) at dilution 1/45. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于URI1抗體的3篇參考文獻(xiàn),按領(lǐng)域內(nèi)相關(guān)研究整理:

1. **文獻(xiàn)名稱**:*URI1 interacts with the RPB5 subunit of RNA polymerase II and enhances its degradation in vitro*

**作者**:Gstaiger M. et al.

**摘要**:該研究首次報(bào)道了URI1蛋白與RNA聚合酶II亞基RPB5的相互作用,通過免疫共沉淀和Western blot(使用特異性URI1抗體)證實(shí)了二者結(jié)合,并發(fā)現(xiàn)URI1可能通過泛素化通路調(diào)控RPB5的穩(wěn)定性。

2. **文獻(xiàn)名稱**:*URI1 promotes tumorigenesis in hepatocellular carcinoma by activating the AKT signaling pathway*

**作者**:Jia Y. et al.

**摘要**:研究利用URI1抗體進(jìn)行免疫組化分析肝癌組織樣本,發(fā)現(xiàn)URI1高表達(dá)與AKT通路激活相關(guān),并通過基因沉默實(shí)驗(yàn)證明其通過調(diào)控AKT磷酸化促進(jìn)肝癌細(xì)胞增殖。

3. **文獻(xiàn)名稱**:*The role of URI1 in chemoresistance of colorectal cancer via mitochondrial apoptosis pathway*

**作者**:Hasegawa K. et al.

**摘要**:通過流式細(xì)胞術(shù)和Western blot(使用抗URI1抗體)發(fā)現(xiàn),URI1過表達(dá)抑制線粒體凋亡通路,導(dǎo)致結(jié)直腸癌細(xì)胞對(duì)化療藥物耐藥,提示其作為潛在治療靶點(diǎn)。

注:以上文獻(xiàn)為模擬示例,實(shí)際引用需根據(jù)具體研究核實(shí)。建議通過PubMed或Google Scholar以關(guān)鍵詞“URI1 antibody”、“URI1 function”檢索最新文獻(xiàn)。

       

背景信息

The URI1 antibody is a research tool designed to detect URI1 (Unconventional prefoldin RPB5 Interactor 1), a protein involved in diverse cellular processes, including transcriptional regulation, stress response, and chromatin remodeling. URI1. also known as RMP or SPRETUS19. functions as part of the prefoldin-like complex, acting as a molecular chaperone that stabilizes RNA polymerase II subunits and modulates transcriptional activity. It interacts with components of the PFDN family and other partners like RPB5 (POLR2E), linking it to pathways such as mTOR signaling and mitochondrial function.

First identified in yeast, URI1 is evolutionarily conserved and plays roles in embryogenesis, cell proliferation, and tumorigenesis. Dysregulation of URI1 has been implicated in cancers, metabolic disorders, and neurological diseases, making it a potential therapeutic target. The URI1 antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study its expression patterns, subcellular localization (primarily cytoplasmic and nuclear), and interactions in both normal and pathological contexts. Its development has facilitated insights into URI1's dual role as an oncogene or tumor suppressor, depending on cellular context, and its involvement in stress adaptation mechanisms. Validation of antibody specificity through knockout controls remains critical due to cross-reactivity risks.

       
關(guān)鍵字: URI1抗體;URI1;URI1 Antibody;

公司簡(jiǎn)介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營(yíng)行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

URI1抗體;URI1 Antibody—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
詢價(jià)
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費(fèi)雪(杭州)醫(yī)學(xué)研究有限公司
2025-07-28
詢價(jià)
上海華盈生物醫(yī)藥科技有限公司
2025-08-02
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