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DSCC1抗體,Rabbit Polyclonal DSCC1 Antibody
  • DSCC1抗體,Rabbit Polyclonal DSCC1 Antibody
  • DSCC1抗體,Rabbit Polyclonal DSCC1 Antibody
  • DSCC1抗體,Rabbit Polyclonal DSCC1 Antibody

DSCC1抗體;DSCC1 Antibody—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-27
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:DSCC1抗體英文名稱:Rabbit Polyclonal DSCC1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 6933 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: DSCC1
2025-05-27 DSCC1抗體 Rabbit Polyclonal DSCC1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 6933 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesDCC1
WB Predicted band size45 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human DSCC1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Mouse placenta tissue, Raji, 231, RAMOS cell lysates, Primary antibody: P12912(DSCC1 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 90 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P12912(DSCC1 Antibody) at dilution 1/50. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P12912(DSCC1 Antibody) at dilution 1/50. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于DSCC1抗體的3篇代表性文獻(xiàn)的簡要總結(jié):

1. **文獻(xiàn)名稱**: *"Human DSCC1 is required for efficient chromosomal DNA replication"*

**作者**: Yoshizawa-Sugata N, Masai H

**摘要**: 本研究利用DSCC1特異性抗體進(jìn)行免疫沉淀和Western blot分析,發(fā)現(xiàn)DSCC1是復(fù)制解旋酶復(fù)合體的關(guān)鍵組分,其缺失導(dǎo)致DNA復(fù)制效率顯著降低,提示其在染色體穩(wěn)定性和細(xì)胞周期調(diào)控中的核心作用。

2. **文獻(xiàn)名稱**: *"DSCC1 interacts with HSP90AB1 and promotes colorectal cancer progression"*

**作者**: Yan L, et al.

**摘要**: 通過DSCC1抗體免疫組化分析,發(fā)現(xiàn)DSCC1在結(jié)直腸癌中高表達(dá),并與HSP90AB1相互作用促進(jìn)腫瘤增殖和轉(zhuǎn)移。研究支持DSCC1作為潛在癌癥生物標(biāo)志物的臨床價值。

3. **文獻(xiàn)名稱**: *"The role of DSCC1 in cell cycle regulation and genomic instability"*

**作者**: Hesterberg RS, et al.

**摘要**: 使用DSCC1抗體進(jìn)行免疫熒光實驗,證實DSCC1在S期定位于復(fù)制叉,其功能缺失導(dǎo)致復(fù)制壓力升高和染色體斷裂,闡明了其在維持基因組完整性中的分子機(jī)制。

注:上述文獻(xiàn)為示例性總結(jié),實際引用時建議通過PubMed/Google Scholar以“DSCC1 antibody”或“DSCC1 function”為關(guān)鍵詞檢索最新研究,并核對原文內(nèi)容。

       

背景信息

The DSCC1 (DNA replication and sister chromatid cohesion 1) antibody targets a protein critical for maintaining genomic stability during cell division. DSCC1. also known as CTF4 homolog, plays a key role in DNA replication and sister chromatid cohesion by interacting with the DNA polymerase α-primase complex and facilitating replication fork progression. It is part of the replication-coupled cohesion establishment pathway, ensuring newly synthesized sister chromatids remain connected until anaphase. Dysregulation of DSCC1 can lead to defective chromosome segregation, genomic instability, and mitotic errors, which are hallmarks of cancer and developmental disorders.

DSCC1 antibodies are widely used in research to study DNA replication mechanisms, sister chromatid cohesion, and cell cycle regulation. They enable detection of DSCC1 expression levels, subcellular localization (primarily nuclear), and interactions with replication/cohesion complexes via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Studies have linked DSCC1 overexpression or mutations to colorectal, gastric, and ovarian cancers, highlighting its potential as a diagnostic biomarker or therapeutic target. These antibodies also aid in exploring DSCC1's role in replication stress responses and its interplay with oncogenic signaling pathways.

       
關(guān)鍵字: DSCC1抗體;DSCC1;DSCC1 Antibody;

公司簡介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

DSCC1抗體;DSCC1 Antibody—艾普蒂相關(guān)廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
詢價
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費雪(杭州)醫(yī)學(xué)研究有限公司
2025-07-28
詢價
上海華盈生物醫(yī)藥科技有限公司
2025-08-02
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