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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P12799(ADAMTS7 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12799(ADAMTS7 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The ADAMTS7 antibody is a research tool designed to detect and study ADAMTS7. a member of the ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) family of extracellular proteases. ADAMTS7 is implicated in extracellular matrix (ECM) remodeling, inflammation, and pathologies such as osteoarthritis, atherosclerosis, and cancer. Its enzymatic activity degrades cartilage oligomeric matrix protein (COMP) and other ECM components, influencing tissue structure and cellular signaling. Dysregulation of ADAMTS7 is linked to vascular calcification, joint degeneration, and tumor progression, making it a potential therapeutic target.

Antibodies against ADAMTS7 are commonly used in techniques like immunohistochemistry, Western blotting, and ELISA to assess protein expression, localization, and activity in biological samples. These antibodies often target specific domains, such as the catalytic metalloproteinase domain or thrombospondin type-1 motifs, enabling functional studies on protease activity or protein-protein interactions. Monoclonal and polyclonal variants are commercially available, with validation data confirming specificity in human, mouse, or rat models.

Recent studies highlight ADAMTS7's role in cardiovascular diseases, particularly atherosclerosis, where its overexpression correlates with plaque instability. In arthritis, it contributes to cartilage breakdown, spurring interest in inhibitory antibodies for disease modification. Researchers also explore its utility as a biomarker for disease progression. However, challenges remain in understanding its full mechanistic spectrum and optimizing antibody-based therapies. Ongoing work aims to clarify its dual roles in tissue homeostasis and pathology, driving demand for reliable ADAMTS7-targeting reagents.