+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12794(ABCA6 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The ABCA6 antibody is a tool used to study the ATP-binding cassette subfamily A member 6 (ABCA6), a protein encoded by the ABCA6 gene in humans. ABCA6 belongs to the ATP-binding cassette (ABC) transporter superfamily, which is characterized by transmembrane proteins that hydrolyze ATP to transport various substrates across cellular membranes. While ABCA6's exact physiological role remains unclear, it is hypothesized to participate in lipid metabolism, potentially regulating cholesterol or phospholipid transport. This protein is primarily expressed in the liver and may influence cellular lipid homeostasis, though its function is less understood compared to other ABCA family members like ABCA1 (critical in cholesterol efflux) or ABCA4 (involved in retinal metabolism).

Research on ABCA6 is limited, but studies suggest associations with metabolic disorders. For instance, genetic variations in ABCA6 have been linked to altered serum cholesterol levels and cardiovascular diseases, such as atherosclerosis. ABCA6 antibodies enable detection and localization of the protein in tissues or cell lines, aiding investigations into its expression patterns under physiological or pathological conditions. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, or flow cytometry. Despite its potential relevance, ABCA6 remains understudied, partly due to functional redundancy within the ABCA subfamily and a lack of definitive mechanistic insights. Ongoing research aims to clarify its biological role and therapeutic implications in lipid-related diseases.