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KNL1抗體,Rabbit Polyclonal KNL1 Antibody
  • KNL1抗體,Rabbit Polyclonal KNL1 Antibody
  • KNL1抗體,Rabbit Polyclonal KNL1 Antibody
  • KNL1抗體,Rabbit Polyclonal KNL1 Antibody

KNL1抗體;KNL1 Antibody—艾普蒂 新品

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-26
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:KNL1抗體英文名稱:Rabbit Polyclonal KNL1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 6792 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: KNL1
2025-05-26 KNL1抗體 Rabbit Polyclonal KNL1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 6792 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesD40; CT29; Spc7; CASC5; MCPH4; hKNL-1; AF15Q14; PPP1R55; hSpc105
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human KNL1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P12702(KNL1 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12702(KNL1 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

參考文獻

以下是關(guān)于KNL1抗體的3篇示例參考文獻及其摘要概括(注:文獻為示例性內(nèi)容,實際引用請通過學(xué)術(shù)數(shù)據(jù)庫核實):

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1. **文獻名稱**: *"KNL1 is a key regulator of microtubule attachment and spindle checkpoint signaling"*

**作者**: Cheeseman, I.M., et al.

**摘要概括**: 該研究利用KNL1特異性抗體,通過免疫熒光和免疫印跡分析,揭示了KNL1在動粒介導(dǎo)的微管附著及紡錘體檢查點信號傳導(dǎo)中的核心作用。研究發(fā)現(xiàn)KNL1缺失導(dǎo)致染色體錯誤分離,并闡明了其與BUB1激酶的相互作用機制。

2. **文獻名稱**: *"Phosphorylation-dependent regulation of KNL1 in chromosome segregation fidelity"*

**作者**: Vleugel, M., et al.

**摘要概括**: 研究通過KNL1抗體檢測磷酸化修飾,發(fā)現(xiàn)Aurora B激酶介導(dǎo)的KNL1磷酸化對維持染色體分離精度至關(guān)重要。實驗結(jié)合RNA干擾和活細胞成像,表明磷酸化位點突變會破壞動粒-微管穩(wěn)定性。

3. **文獻名稱**: *"Mutations in KNL1 cause primary microcephaly by disrupting mitotic progression"*

**作者**: Kiyomitsu, T., et al.

**摘要概括**: 該研究在小頭畸形患者中發(fā)現(xiàn)KNL1基因突變,利用KNL1抗體進行免疫組化和蛋白質(zhì)印跡,證實突變導(dǎo)致蛋白表達異常及有絲分裂延遲,揭示了KNL1在神經(jīng)發(fā)育中的病理機制。

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**備注**:

- 以上文獻為基于KNL1相關(guān)研究的常見方向構(gòu)造的示例,實際文獻需通過PubMed、Google Scholar等平臺以關(guān)鍵詞“KNL1 antibody”“CASC5 immune localization”等檢索。

- KNL1(又稱CASC5)在癌癥及遺傳病中的研究可能涉及抗體應(yīng)用,建議結(jié)合具體研究領(lǐng)域篩選文獻。

       

背景信息

The KNL1 antibody is a crucial tool in studying the kinetochore-associated protein KNL1 (Kinetochore Null 1), also known as CASC5 (Cancer Susceptibility Candidate 5). KNL1 is a scaffold protein localized at the kinetochore, a multi-protein structure essential for proper chromosome segregation during mitosis and meiosis. It plays a pivotal role in the spindle assembly checkpoint (SAC), a surveillance mechanism ensuring accurate chromosome attachment to spindle microtubules before anaphase. KNL1 recruits other SAC components, such as BUB1 and BUBR1. and facilitates the assembly of checkpoint signaling complexes. Dysregulation of KNL1 is linked to chromosomal instability, mitotic errors, and diseases like cancer or developmental disorders.

KNL1 antibodies are widely used in research to investigate kinetochore dynamics, SAC function, and mitotic regulation. They enable detection of KNL1 expression via techniques like Western blotting, immunofluorescence, and immunoprecipitation, helping to elucidate its interaction networks and post-translational modifications. Studies using these antibodies have revealed KNL1's role in recruiting PP1 phosphatases to counteract Aurora B kinase activity, promoting stable microtubule attachments. Additionally, KNL1 mutations identified in human cancers and microcephaly-related syndromes highlight its clinical relevance. The antibody serves as a key reagent in both basic cell biology research and translational studies aiming to understand genome integrity mechanisms and develop therapeutic strategies targeting mitotic errors.

       
關(guān)鍵字: KNL1抗體;KNL1;KNL1 Antibody;

公司簡介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細胞培養(yǎng),蛋白組學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

KNL1抗體;KNL1 Antibody—艾普蒂相關(guān)廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
詢價
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費雪(杭州)醫(yī)學(xué)研究有限公司
2025-07-28
詢價
上海華盈生物醫(yī)藥科技有限公司
2025-08-02
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