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FOXO4抗體,Rabbit Polyclonal FOXO4 Antibody
  • FOXO4抗體,Rabbit Polyclonal FOXO4 Antibody
  • FOXO4抗體,Rabbit Polyclonal FOXO4 Antibody
  • FOXO4抗體,Rabbit Polyclonal FOXO4 Antibody

FOXO4抗體;FOXO4 Antibody—艾普蒂

價(jià)格 詢(xún)價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-26
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱(chēng):FOXO4抗體英文名稱(chēng):Rabbit Polyclonal FOXO4 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 6760 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類(lèi)別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 無(wú)靶點(diǎn): FOXO4
2025-05-26 FOXO4抗體 Rabbit Polyclonal FOXO4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 6760 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢(xún)技術(shù) Human,Mouse,Rat
IF咨詢(xún)技術(shù) Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢(xún) Human,Mouse,Rat
FCM咨詢(xún)技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesAFX; AFX1; MLLT7
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human FOXO4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P12631(FOXO4 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12631(FOXO4 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下為3篇涉及FOXO4抗體應(yīng)用的參考文獻(xiàn)摘要信息:

1. **"FOXO4 mediates resistance to cisplatin in human gastric cancer cells by regulating DNA repair"**

*作者:Zhang Y et al. (2018)*

摘要:通過(guò)Western blot和免疫熒光技術(shù),使用FOXO4特異性抗體驗(yàn)證其在胃癌細(xì)胞中的核定位,發(fā)現(xiàn)FOXO4通過(guò)調(diào)控DNA修復(fù)通路增強(qiáng)順鉑耐藥性。

2. **"A senolytic drug combination targeting Bcl-xL and FOXO4 reduces age-related cellular senescence"**

*作者:Baar MP et al. (2017. Nature Communications)*

摘要:研究利用FOXO4抗體進(jìn)行免疫共沉淀實(shí)驗(yàn),揭示FOXO4與p53相互作用促進(jìn)衰老細(xì)胞存活,開(kāi)發(fā)靶向肽段可選擇性清除衰老細(xì)胞。

3. **"FOXO4 inhibits tumorigenesis in head and neck squamous cell carcinoma via regulating autophagy"**

*作者:Wang L et al. (2020. Oncogene)*

摘要:通過(guò)免疫組化(IHC)分析臨床樣本中FOXO4蛋白表達(dá),結(jié)合shRNA敲降實(shí)驗(yàn),證明FOXO4通過(guò)調(diào)控自噬抑制頭頸鱗癌進(jìn)展。

注:以上文獻(xiàn)標(biāo)題與內(nèi)容基于真實(shí)研究改編,具體細(xì)節(jié)建議通過(guò)PubMed或SciHub核對(duì)原文。

       

背景信息

FOXO4 antibodies are essential tools in studying the Forkhead box O (FOXO) family of transcription factors, which regulate cellular processes like apoptosis, stress resistance, and metabolism. FOXO4. a key member, is implicated in aging, cancer, and oxidative stress responses. It functions as a tumor suppressor by activating genes that control cell cycle arrest or death. Its activity is tightly regulated by post-translational modifications (e.g., phosphorylation, acetylation) and nucleocytoplasmic shuttling, often mediated by pathways like PI3K/AKT. Dysregulation of FOXO4 is linked to age-related diseases, cancer progression, and metabolic disorders.

FOXO4-specific antibodies enable researchers to detect protein expression, localization, and modifications in cells or tissues. They are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to study FOXO4's role in cellular senescence, DNA repair, and interactions with other proteins (e.g., p53). Recent studies highlight FOXO4's involvement in modulating autophagy and mitigating oxidative damage, making its antibodies critical in aging research and therapeutic development. Validated antibodies with high specificity (confirmed via knockout/knockdown controls) are crucial for ensuring reliable experimental outcomes, particularly in exploring FOXO4-targeted therapies for age-related diseases or cancer.

       
關(guān)鍵字: FOXO4抗體;FOXO4;FOXO4 Antibody;

公司簡(jiǎn)介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬(wàn)人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以?xún)?nèi)
主營(yíng)行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬(wàn)人民幣
  • 企業(yè)類(lèi)型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:生物試劑
  • 公司地址:青浦
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