鹽酸RGX-104|T5128|TargetMol

價格	￥343	￥496	￥993
包裝	1mg	2mg	5mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2025-07-28

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產(chǎn)品詳情

中文名稱:鹽酸RGX-104	英文名稱:RGX-104 hydrochloride
CAS:610318-03-1	品牌: TargetMol
產(chǎn)地: 美國	保存條件: keep away from direct sunlight,keep away from moisture,store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 99.06%	產(chǎn)品類別: 抑制劑
貨號: T5128

Product Introduction

Bioactivity

名稱	RGX-104 hydrochloride
描述	RGX-104 hydrochloride (SB742881) is a liver X receptor (LXR) agonist with potential immunomodulating and antineoplastic activities. It modulates innate immunity via transcriptional activation of the ApoE gene.
細胞實驗	Myeloid-derived suppressor cells were isolated as previously described from splenic tissue of tumor-bearing mice. One hundred thousand cells were plated in quadruplicates in poly-L-lysine coated plates. After 3 hours of treatment with 1uM RGX-104 or DMSO as vehicle, cells were fixed with 4% PFA for 15 minutes and wash 3 times with 1X PBS prior staining. Rabbit monoclonal anti-Ki67 antibody (1:400 dilution) was applied at 4C overnight. Cells were incubated with Alexa Fluor 488 secondary antibody (1:200 dilution) for one hour at room temperature, counterstained with DAPI (1:1000 dilution) and mounted with Prolong Gold. For the analysis of the percentage of Ki67 positive cells, five fields from each replicate were imaged at 20x magnification using Zeiss Axio Imager fluorescence microscope.
動物實驗	For MDSC adoptive transfer experiments into tumor-bearing mice, 2 × 10^6 MDSCs were isolated as described above from C57BL/6 tumor-bearing mice and subsequently labeled with BD Horizon Violet (BV) Proliferation Dye and then adoptively transferred via retro-orbital injection into wild-type mice. Mice were then treated with RGX-104 (100 mg/kg/day) or control diet for 36 hours. Spleens of recipient mice were then harvested and processed for flow cytometry analysis as described above. For MDSC adoptive transfer experiments in to WT and ApoE?/? non-tumor bearing mice, 5 × 10^6 MDSCs were isolated as described above from tumor-bearing mice (either wild-type C57BL/6 or Apoe?/? mice) and subsequently labeled with BV cell tracker dye and then adoptively transferred via retro-orbital injection into either wild-type or Apoe?/? mice. Mice were then treated with GW3965 (100 mg/kg/day) or control diet for 48 hours. Spleens of recipient mice were then harvested and processed for flow cytometry analysis.
體內(nèi)活性	通過口服給予動物RGX-104顯著抑制了多種癌癥類型的可觸及腫瘤生長。在攜帶大型腫瘤的動物中，也觀察到強烈的腫瘤生長抑制作用。與對照組相比，經(jīng)過8天的治療后，以RGX-104（100 mg/kg）處理的小鼠中，總CD45+淋巴細胞中凋亡性循環(huán)G-MDSCs顯著增加。
存儲條件	keep away from direct sunlight,keep away from moisture,store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 115 mg/mL (181.81 mM), Sonication is recommended.
關(guān)鍵字	SB-742881 \| SB 742881 \| RGX-104 Hydrochloride \| RGX104 hydrochloride \| RGX104 Hydrochloride \| RGX-104 \| RGX104 \| RGX 104 hydrochloride \| RGX 104 Hydrochloride \| RGX 104 \| LXR \| LiverXReceptor \| Liver X receptor \| Liver X Receptor \| Inhibitor \| inhibit
相關(guān)產(chǎn)品	SR9243 \| (20S)-Protopanaxatriol \| T0901317 \| GW6340 \| Rovazolac \| GSK2033 \| SR9238 \| RGX-104 \| LXR-623 \| GW3965 hydrochloride \| BE1218 \| GAC0003A4
相關(guān)庫	抗癌活性化合物庫 \| NO PAINS 化合物庫 \| 血液病分子庫 \| 核受體化合物庫 \| 臨床期小分子藥物庫 \| 口服活性化合物庫 \| 抗代謝疾病化合物庫 \| 抗癌臨床化合物庫 \| 抗癌藥物庫

關(guān)鍵字：鹽酸RGX-104|||SB742881|||RGX-104 HCl|TargetMol

公司簡介

TargetMol Chemicals Inc. 總部位于馬薩諸塞州波士頓，致力于為全球生化領(lǐng)域科學家的研究提供專業(yè)的產(chǎn)品和服務(wù)。TargetMol?品牌的客戶群分布于40多個國家和地區(qū)，已發(fā)展成為全球知名的化合物庫和小分子化合物研究供應(yīng)商。 TargetMol?可提供160多種滿足不同需求的化合物庫，以及多種類型的生化試劑產(chǎn)品，包括12000多種抑制劑、16000多種天然產(chǎn)物和各類多肽、抗體、生命科學試劑盒等，此外，我們還建設(shè)有CADD（計算機輔助藥物設(shè)計）研究中心、藥理實驗室、藥化合成平臺三大技術(shù)中心，全方位滿足客戶的定制需求。憑借我們優(yōu)質(zhì)的產(chǎn)品和服務(wù)、快速高效的全球供應(yīng)鏈和專業(yè)的技術(shù)支持，我們將有效幫助您縮短研發(fā)周期，取得更成功的結(jié)果。

成立日期	2013-04-18 （13年）	注冊資本	566.265100萬人民幣
員工人數(shù)	100-500人	年營業(yè)額	￥ 1億以上
主營行業(yè)	天然產(chǎn)物,生化試劑,分子生物學,分子砌塊,生物技術(shù)服務(wù)	經(jīng)營模式	貿(mào)易,工廠,試劑,定制,服務(wù)

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公司成立：13年
注冊資本：566.265100萬人民幣
企業(yè)類型：有限責任公司(自然人投資或控股)
主營產(chǎn)品：小分子抑制劑、藥物篩選化合物庫、藥物篩選等
公司地址：靜安區(qū)江場三路238號8樓

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