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PRDX4抗體,Rabbit Polyclonal PRDX4 Antibody
  • PRDX4抗體,Rabbit Polyclonal PRDX4 Antibody
  • PRDX4抗體,Rabbit Polyclonal PRDX4 Antibody
  • PRDX4抗體,Rabbit Polyclonal PRDX4 Antibody

PRDX4抗體;PRDX4 Antibody—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-26
QQ交談 微信洽談

產品詳情

中文名稱:PRDX4抗體英文名稱:Rabbit Polyclonal PRDX4 Antibody
品牌: 艾普蒂產地: 武漢
保存條件: Stored at -20°C for 6737 year. Avoid repeated freeze / thaw cycles.產品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: PRDX4
2025-05-26 PRDX4抗體 Rabbit Polyclonal PRDX4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 6737 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術 Human,Mouse,Rat
IF咨詢技術 Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技術咨詢 Human,Mouse,Rat
FCM咨詢技術 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產品詳情

AliasesPRX-4; AOE372; AOE37-2; HEL-S-97n
WB Predicted band size30 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human PRDX4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-6: MCF-7, K562, HepG2, 293T, Raji and Hela cell, Primary antibody: P12590(PRDX4 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30S    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12590(PRDX4 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12590(PRDX4 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

參考文獻

以下是關于PRDX4抗體的3篇代表性文獻,內容涵蓋功能研究、疾病關聯(lián)及抗體應用方向:

1. **文獻名稱**: *"Peroxiredoxin 4 suppresses anoikis and promotes tumorigenesis in hepatocellular carcinoma"*

**作者**: Wei et al. (2018)

**摘要**: 研究通過PRDX4抗體檢測肝癌組織中PRDX4蛋白表達,發(fā)現(xiàn)其高表達與腫瘤轉移和不良預后相關。實驗表明PRDX4通過抑制氧化應激保護細胞失巢凋亡(anoikis),促進肝癌進展。

2. **文獻名稱**: *"A novel monoclonal antibody against human peroxiredoxin 4 for immunoblotting and immunohistochemical analysis"*

**作者**: Yamaguchi et al. (2015)

**摘要**: 報道了一種特異性識別PRDX4的單克隆抗體的開發(fā)與驗證,證實其在Western blot和免疫組化中的高靈敏度和特異性,為PRDX4在組織中的定位和定量分析提供可靠工具。

3. **文獻名稱**: *"PRDX4 interacts with insulin-like growth factor 1 receptor to regulate neuronal oxidative stress and apoptosis"*

**作者**: Li et al. (2020)

**摘要**: 利用PRDX4抗體進行共免疫沉淀實驗,發(fā)現(xiàn)PRDX4與胰島素樣生長因子受體(IGF-1R)相互作用,調節(jié)神經元氧化應激和凋亡,提示其在神經退行性疾病中的潛在作用。

4. **文獻名稱**: *"Circulating peroxiredoxin 4 as a diagnostic biomarker for type 2 diabetes mellitus"*

**作者**: Kim et al. (2019)

**摘要**: 通過ELISA(基于PRDX4抗體)檢測糖尿病患者血清PRDX4水平,發(fā)現(xiàn)其顯著升高且與胰島素抵抗相關,提出PRDX4可能作為2型糖尿病的新型生物標志物。

注:以上文獻信息為示例性質,實際引用時建議通過PubMed/Google Scholar核對原文。

       

背景信息

The PRDX4 (Peroxiredoxin 4) antibody is a crucial tool for studying the PRDX4 protein, a member of the peroxiredoxin family involved in cellular antioxidant defense. PRDX4 functions as a thiol-specific peroxidase, neutralizing reactive oxygen species (ROS) like hydrogen peroxide to protect cells from oxidative damage. Unlike other peroxiredoxins (PRDX1-6), PRDX4 is unique as a secreted protein, synthesized with a signal peptide that directs its transport to the endoplasmic reticulum (ER) and extracellular spaces. This secretory feature allows PRDX4 to regulate redox signaling both intracellularly and in extracellular environments, influencing processes such as protein folding, inflammation, and apoptosis.

PRDX4 antibodies are widely used in research to detect and quantify PRDX4 expression in tissues and cells via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help elucidate PRDX4's roles in diseases linked to oxidative stress, including cancer, neurodegenerative disorders (e.g., Alzheimer’s), diabetes, and cardiovascular conditions. For example, elevated PRDX4 levels in certain cancers correlate with tumor progression and drug resistance, while its deficiency is implicated in ER stress-related pathologies.

High-quality PRDX4 antibodies exhibit specificity for epitopes within conserved regions of the protein, ensuring minimal cross-reactivity with other PRDX isoforms. Researchers rely on these reagents to explore PRDX4's dual functions as an antioxidant and a redox-dependent signaling modulator, advancing therapeutic strategies targeting oxidative damage pathways.

       
關鍵字: PRDX4抗體;PRDX4;PRDX4 Antibody;

公司簡介

生物技術有限公司
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內
主營行業(yè) 抗體,植物生物技術,細胞培養(yǎng),蛋白組學 經營模式 貿易,工廠,試劑,定制,服務
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產品:生物試劑
  • 公司地址:青浦
詢盤

PRDX4抗體;PRDX4 Antibody—艾普蒂相關廠家報價

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