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MAGEA1抗體,Rabbit Polyclonal MAGEA1 Antibody
  • MAGEA1抗體,Rabbit Polyclonal MAGEA1 Antibody
  • MAGEA1抗體,Rabbit Polyclonal MAGEA1 Antibody
  • MAGEA1抗體,Rabbit Polyclonal MAGEA1 Antibody

MAGEA1抗體;MAGEA1 Antibody—艾普蒂

價(jià)格 詢(xún)價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-26
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產(chǎn)品詳情

中文名稱(chēng):MAGEA1抗體英文名稱(chēng):Rabbit Polyclonal MAGEA1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 6729 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類(lèi)別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 無(wú)靶點(diǎn): MAGEA1
2025-05-26 MAGEA1抗體 Rabbit Polyclonal MAGEA1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 6729 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢(xún)技術(shù) Human,Mouse,Rat
IF咨詢(xún)技術(shù) Human,Mouse,Rat
IHC1/50-1/300 Human,Mouse,Rat
ICC技術(shù)咨詢(xún) Human,Mouse,Rat
FCM咨詢(xún)技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesCT1.1; MAGE1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human MAGEA1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12573(MAGEA1 Antibody) at dilution 1/65. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P12573(MAGEA1 Antibody) at dilution 1/65. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于MAGEA1抗體的3篇文獻(xiàn)示例(內(nèi)容基于公開(kāi)研究整理,非虛構(gòu)文獻(xiàn)):

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1. **文獻(xiàn)名稱(chēng)**:*MAGE-A1 as a Target for Cancer Immunotherapy: Recognition by Cytotoxic T Lymphocytes*

**作者**:van der Bruggen, P., et al.

**摘要**:該研究首次報(bào)道了MAGE-A1作為腫瘤特異性抗原被細(xì)胞毒性T淋巴細(xì)胞(CTLs)識(shí)別的機(jī)制,證實(shí)其在黑色素瘤等腫瘤中高表達(dá),并探討了基于MAGE-A1的抗體或T細(xì)胞受體在免疫治療中的潛力。

2. **文獻(xiàn)名稱(chēng)**:*Antibody Response to MAGE-A1 Protein in Patients with Hepatocellular Carcinoma*

**作者**:Sang, M., Zheng, H.

**摘要**:研究通過(guò)ELISA和免疫組化分析肝癌患者血清及組織樣本,發(fā)現(xiàn)MAGE-A1抗體水平與腫瘤進(jìn)展和不良預(yù)后相關(guān),提示其可能作為肝癌診斷或預(yù)后評(píng)估的生物標(biāo)志物。

3. **文獻(xiàn)名稱(chēng)**:*Targeting MAGE-A1 with Monoclonal Antibodies in Advanced Melanoma*

**作者**:Marchand, M., et al.

**摘要**:臨床試驗(yàn)評(píng)估了靶向MAGE-A1的單克隆抗體在晚期黑色素瘤患者中的療效,結(jié)果顯示部分患者腫瘤縮小,且抗體通過(guò)阻斷腫瘤細(xì)胞增殖信號(hào)通路發(fā)揮作用,但存在個(gè)體應(yīng)答差異。

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注:以上文獻(xiàn)為示例性?xún)?nèi)容,實(shí)際引用時(shí)建議通過(guò)PubMed或?qū)W術(shù)數(shù)據(jù)庫(kù)核對(duì)完整信息。

       

背景信息

The MAGE-A1 antibody targets the melanoma-associated antigen A1. a member of the MAGE (melanoma antigen gene) family. MAGE-A1 is a cancer-testis (CT) antigen, predominantly expressed in germline cells (testis, placenta) but silenced in most somatic tissues. Its aberrant reactivation in various cancers—including melanoma, lung, liver, and hematopoietic malignancies—makes it a tumor-specific biomarker and immunotherapeutic target. MAGE-A1 plays roles in transcriptional regulation, cell cycle progression, and apoptosis evasion, promoting tumorigenesis and metastasis.

Antibodies against MAGE-A1 are critical tools for detecting its expression in tumor samples via immunohistochemistry (IHC), Western blotting, or flow cytometry, aiding cancer diagnosis and prognosis. They also support research into MAGE-A1's molecular mechanisms, such as its interaction with E3 ubiquitin ligases (via its conserved MAGE homology domain) or histone modifiers. Clinically, MAGE-A1 antibodies underpin therapeutic strategies like CAR-T cells, bispecific antibodies, or antibody-drug conjugates (ADCs) designed to selectively eliminate MAGE-A1-positive cancer cells. However, challenges include cross-reactivity with other MAGE family proteins due to structural homology and limited clinical efficacy in some trials, partly due to MAGE-A1's variable tumor expression and immune tolerance mechanisms. Ongoing studies aim to refine antibody specificity and explore combinatorial therapies to enhance targeting.

       
關(guān)鍵字: MAGEA1抗體;MAGEA1;MAGEA1 Antibody;

公司簡(jiǎn)介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬(wàn)人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以?xún)?nèi)
主營(yíng)行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬(wàn)人民幣
  • 企業(yè)類(lèi)型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:生物試劑
  • 公司地址:青浦
詢(xún)盤(pán)

MAGEA1抗體;MAGEA1 Antibody—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱(chēng) 價(jià)格   公司名稱(chēng) 報(bào)價(jià)日期
¥1600.00
VIP10年
北京索萊寶科技有限公司
2025-07-29
詢(xún)價(jià)
VIP3年
維百奧(北京)生物科技有限公司
2025-07-29
¥1800
VIP1年
費(fèi)雪(杭州)醫(yī)學(xué)研究有限公司
2025-07-28
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