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STARD4抗體,Rabbit Polyclonal STARD4 Antibody
  • STARD4抗體,Rabbit Polyclonal STARD4 Antibody
  • STARD4抗體,Rabbit Polyclonal STARD4 Antibody
  • STARD4抗體,Rabbit Polyclonal STARD4 Antibody

STARD4抗體;STARD4 Antibody—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-26
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:STARD4抗體英文名稱:Rabbit Polyclonal STARD4 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 6535 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: STARD4
2025-05-26 STARD4抗體 Rabbit Polyclonal STARD4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 6535 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

WB Predicted band size24 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human STARD4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: HepG2 cell, Human liver tissue, Mouse liver tissue, Human fetal liver tissue, LO2 cell lysates, Primary antibody: P12247(STARD4 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P12247(STARD4 Antibody) at dilution 1/50. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P12247(STARD4 Antibody) at dilution 1/50. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于STARD4抗體的3篇參考文獻(xiàn)示例(內(nèi)容為模擬概括,建議通過數(shù)據(jù)庫核實原文):

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1. **文獻(xiàn)名稱**: *"STARD4 mediates macrophage cholesterol efflux and promotes reverse cholesterol transport"*

**作者**: Kanno K, et al.

**摘要**: 本研究利用STARD4特異性抗體,驗證了該蛋白在巨噬細(xì)胞中的表達(dá)定位。實驗表明,STARD4通過促進(jìn)膽固醇從細(xì)胞內(nèi)向HDL的轉(zhuǎn)運,減少泡沫細(xì)胞形成,提示其在動脈粥樣硬化中的潛在保護(hù)作用。

2. **文獻(xiàn)名稱**: *"Regulation of STARD4 expression in hepatic cells by LXR and SREBP pathways"*

**作者**: Rodriguez-Agudo D, et al.

**摘要**: 通過Western blot和免疫熒光(使用兔源STARD4多克隆抗體),發(fā)現(xiàn)肝細(xì)胞中STARD4的表達(dá)受LXR和SREBP轉(zhuǎn)錄因子雙重調(diào)控,并參與肝細(xì)胞內(nèi)膽固醇的儲存與運輸調(diào)控。

3. **文獻(xiàn)名稱**: *"Characterization of the STAR protein family: Focus on STARD4's role in cellular lipid homeostasis"*

**作者**: Soccio RE, et al.

**摘要**: 文章首次報道了針對STARD4蛋白的單克隆抗體制備,并通過免疫印跡驗證其特異性。研究發(fā)現(xiàn)STARD4通過結(jié)合膽固醇并促進(jìn)其在胞內(nèi)運輸,維持脂代謝穩(wěn)態(tài),與Ⅱ型糖尿病發(fā)病風(fēng)險相關(guān)。

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**注意**:以上文獻(xiàn)信息為示例性概括,實際文獻(xiàn)需通過PubMed、Google Scholar等平臺以“STARD4 antibody”或“STARD4 function”為關(guān)鍵詞檢索。若需具體抗體產(chǎn)品文獻(xiàn),可查詢抗體生產(chǎn)商(如Abcam、CST)提供的引用列表。

       

背景信息

The STARD4 antibody is a research tool designed to detect and analyze the STARD4 (StAR-related lipid transfer domain-containing protein 4) protein, a member of the STARD family involved in intracellular cholesterol transport and lipid metabolism. STARD4 facilitates non-vesicular cholesterol movement between membranes, particularly in maintaining cellular cholesterol homeostasis by shuttling cholesterol from the plasma membrane to the endoplasmic reticulum. Its expression is regulated by sterol levels via SREBP (sterol regulatory element-binding protein) pathways, linking it to diseases like atherosclerosis, metabolic syndrome, and cancers where cholesterol dysregulation occurs.

Antibodies against STARD4 enable researchers to study its expression patterns, subcellular localization, and interactions in models of lipid-related disorders. For example, they are used in Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess STARD4 levels in tissues or cultured cells under varying sterol conditions. Commercially available STARD4 antibodies are typically raised in rabbits or mice using immunogenic peptide sequences unique to the protein. Validation often includes knockout cell lines or siRNA-mediated silencing to confirm specificity.

These tools have advanced understanding of STARD4's role in lipid signaling, cancer progression (e.g., hepatocellular carcinoma), and neurodegenerative diseases. However, challenges remain in standardizing antibody performance across experimental platforms. Ongoing research aims to clarify STARD4's mechanistic contributions to cellular cholesterol balance and its potential as a therapeutic target.

       
關(guān)鍵字: STARD4抗體;STARD4;STARD4 Antibody;

公司簡介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

STARD4抗體;STARD4 Antibody—艾普蒂相關(guān)廠家報價

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