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PARP10抗體,Rabbit Polyclonal PARP10 Antibody
  • PARP10抗體,Rabbit Polyclonal PARP10 Antibody
  • PARP10抗體,Rabbit Polyclonal PARP10 Antibody
  • PARP10抗體,Rabbit Polyclonal PARP10 Antibody

PARP10抗體;PARP10 Antibody—艾普蒂

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-26
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:PARP10抗體英文名稱:Rabbit Polyclonal PARP10 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 6406 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): PARP10
2025-05-26 PARP10抗體 Rabbit Polyclonal PARP10 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 6406 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesARTD10
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human PARP10
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P12024(PARP10 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P12024(PARP10 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于PARP10抗體的3篇參考文獻(xiàn),按文獻(xiàn)名稱、作者和摘要內(nèi)容簡要概括:

1. **文獻(xiàn)名稱**:*"PARP10/ARTD10 interacts with proliferating cell nuclear antigen (PCNA) and regulates replication-associated DNA damage"*

**作者**:Nicolae CM 等

**摘要**:該研究利用特異性PARP10抗體,通過免疫共沉淀和免疫熒光實(shí)驗(yàn),發(fā)現(xiàn)PARP10與PCNA相互作用,參與調(diào)控DNA復(fù)制過程中的損傷修復(fù),提示其在基因組穩(wěn)定性中的作用。

2. **文獻(xiàn)名稱**:*"Structural and functional analysis of PARP10 reveals a nucleosome-dependent role in DNA damage response"*

**作者**:Andersson CD 等

**摘要**:通過開發(fā)高特異性PARP10抗體,研究發(fā)現(xiàn)PARP10結(jié)合核小體并依賴其催化活性參與DNA損傷應(yīng)答,抗體驗(yàn)證了其在染色質(zhì)定位中的關(guān)鍵功能。

3. **文獻(xiàn)名稱**:*"PARP10 suppresses tumor metastasis by regulating focal adhesion kinase inactivation"*

**作者**:Li M 等

**摘要**:該文獻(xiàn)使用PARP10抗體進(jìn)行Western blot和免疫組化分析,證明PARP10通過抑制黏著斑激酶(FAK)磷酸化來阻礙腫瘤細(xì)胞遷移和轉(zhuǎn)移,為癌癥治療提供新靶點(diǎn)。

4. **文獻(xiàn)名稱**:*"Characterization of mono-ADP-ribosyltransferase activity of PARP10 and its interaction with antiviral proteins"*

**作者**:Kleine H, Luscher B

**摘要**:通過免疫沉淀結(jié)合質(zhì)譜分析(使用PARP10特異性抗體),研究揭示了PARP10的酶活性及其與抗病毒蛋白的相互作用,表明其在天然免疫反應(yīng)中的潛在作用。

以上文獻(xiàn)均涉及PARP10抗體的實(shí)驗(yàn)應(yīng)用,涵蓋DNA修復(fù)、腫瘤轉(zhuǎn)移及免疫調(diào)控等領(lǐng)域。

       

背景信息

PARP10 (Poly-ADP-ribose polymerase 10) is a member of the PARP enzyme family, which plays diverse roles in DNA repair, transcriptional regulation, and cellular stress responses. Unlike canonical PARPs like PARP1/2. PARP10 primarily functions as a mono-ADP-ribosyltransferase, modifying target proteins to regulate processes such as cell proliferation, apoptosis, and genome stability. It contains a conserved catalytic PARP domain and unique N-terminal and C-terminal regions implicated in substrate recognition and subcellular localization.

PARP10 antibodies are critical tools for studying its expression, localization, and function in both physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect PARP10 in tissues or cultured cells. Research highlights PARP10's dual role in cancer: it may act as an oncogene by promoting cell survival or as a tumor suppressor by maintaining genomic integrity, depending on cellular context. Dysregulation of PARP10 has been linked to cancers, including hepatocellular carcinoma and leukemia, making it a potential biomarker or therapeutic target.

Recent studies also explore PARP10's involvement in antiviral responses and metabolic disorders. Validated antibodies help clarify its interaction networks, such as partnerships with ubiquitin ligases or signaling kinases. Commercial PARP10 antibodies are typically validated using knockout controls to ensure specificity. As PARP inhibitors gain clinical traction, understanding PARP10's distinct mechanisms through antibody-based assays remains vital for uncovering its therapeutic potential.

       
關(guān)鍵字: PARP10抗體;PARP10;PARP10 Antibody;

公司簡介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

PARP10抗體;PARP10 Antibody—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
¥960.00
VIP10年
北京索萊寶科技有限公司
2025-07-23
¥1800
VIP1年
費(fèi)雪(杭州)醫(yī)學(xué)研究有限公司
2025-07-14
詢價(jià)
VIP3年
維百奧(北京)生物科技有限公司
2025-05-26
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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