UHRF2 (Ubiquitin-like with PHD and RING Finger domains 2) is a multifunctional protein involved in epigenetic regulation, particularly in DNA methylation and histone modification. It belongs to the UHRF family, alongside UHRF1. sharing structural similarities such as tandem Tudor, PHD, and RING finger domains. These domains enable UHRF2 to interact with histone marks (e.g., H3K9me3) and DNA, facilitating chromatin remodeling and gene silencing. Unlike UHRF1. which is cell cycle-regulated and critical in maintaining DNA methylation during replication, UHRF2 exhibits broader tissue expression, including high levels in the brain and testes, suggesting roles in neurodevelopment and spermatogenesis.
Antibodies targeting UHRF2 are essential tools for studying its localization, expression, and interactions. They are commonly used in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation to explore UHRF2's involvement in cellular processes such as cell cycle regulation, DNA repair, and apoptosis. Research has linked UHRF2 dysregulation to cancers, neurodegenerative diseases, and developmental disorders, highlighting its therapeutic potential. However, challenges remain in distinguishing UHRF2-specific functions from UHRF1 due to overlapping roles. Validated UHRF2 antibodies are critical for dissecting its unique contributions to epigenetic networks and disease mechanisms.