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KCNQ4抗體,Rabbit Polyclonal KCNQ4 Antibody
  • KCNQ4抗體,Rabbit Polyclonal KCNQ4 Antibody
  • KCNQ4抗體,Rabbit Polyclonal KCNQ4 Antibody
  • KCNQ4抗體,Rabbit Polyclonal KCNQ4 Antibody

KCNQ4抗體;KCNQ4 Antibody—艾普蒂

價(jià)格 詢(xún)價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-26
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱(chēng):KCNQ4抗體英文名稱(chēng):Rabbit Polyclonal KCNQ4 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 6321 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類(lèi)別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 無(wú)靶點(diǎn): KCNQ4
2025-05-26 KCNQ4抗體 Rabbit Polyclonal KCNQ4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 6321 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢(xún)技術(shù) Human,Mouse,Rat
IF咨詢(xún)技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢(xún) Human,Mouse,Rat
FCM咨詢(xún)技術(shù) Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesDFNA2; KV7.4; DFNA2A
WB Predicted band size77 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human KCNQ4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal brain tissue, mouse brain tissue, Primary antibody: P11880(KCNQ4 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 7 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11880(KCNQ4 Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P11880(KCNQ4 Antibody) at dilution 1/40. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是3-4篇關(guān)于KCNQ4抗體的參考文獻(xiàn)及其簡(jiǎn)要摘要:

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1. **文獻(xiàn)名稱(chēng)**:*KCNQ4. a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness*

**作者**:Kubisch C, et al.

**摘要**:該研究首次發(fā)現(xiàn)KCNQ4基因突變與常染色體顯性遺傳性耳聾(DFNA2型)相關(guān),并利用特異性抗體證實(shí)KCNQ4蛋白在外毛細(xì)胞中的表達(dá),提示其在聽(tīng)覺(jué)信號(hào)傳導(dǎo)中的關(guān)鍵作用。

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2. **文獻(xiàn)名稱(chēng)**:*Expression of the KCNQ4 potassium channel in the developing mouse cochlea*

**作者**:Beisel KW, et al.

**摘要**:通過(guò)免疫組化結(jié)合KCNQ4抗體,研究揭示了小鼠耳蝸發(fā)育過(guò)程中KCNQ4通道的時(shí)空表達(dá)模式,表明其參與毛細(xì)胞成熟及聽(tīng)覺(jué)功能的建立。

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3. **文獻(xiàn)名稱(chēng)**:*KCNQ4 channels in the CNS: Unique subcellular distribution and modulation by neuronal activity*

**作者**:Kharkovets T, et al.

**摘要**:利用KCNQ4特異性抗體進(jìn)行亞細(xì)胞定位分析,發(fā)現(xiàn)該通道在特定神經(jīng)元胞體和突觸區(qū)域的富集,并證明其活性受神經(jīng)元電活動(dòng)調(diào)控,可能影響神經(jīng)興奮性平衡。

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4. **文獻(xiàn)名稱(chēng)**:*Molecular structure and physiological function of chloride channels and potassium channels*

**作者**:Jentsch TJ, et al.

**摘要**:綜述中討論了KCNQ家族(包括KCNQ4)的結(jié)構(gòu)與功能,引用抗體相關(guān)實(shí)驗(yàn)數(shù)據(jù)說(shuō)明KCNQ4在聽(tīng)覺(jué)及神經(jīng)系統(tǒng)疾病中的病理機(jī)制。

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注:以上文獻(xiàn)為示例,實(shí)際引用時(shí)需根據(jù)具體研究?jī)?nèi)容核對(duì)作者、年份及期刊信息。

       

背景信息

The KCNQ4 antibody is a research tool designed to detect and study the KCNQ4 protein, a voltage-gated potassium channel subunit encoded by the *KCNQ4* gene. As a member of the Kv7 (KCNQ) family, KCNQ4 plays a critical role in regulating neuronal excitability and auditory function. It is predominantly expressed in the central nervous system, cochlear hair cells, and smooth muscle cells, where it contributes to the maintenance of resting membrane potential and signal transduction. Mutations in *KCNQ4* are linked to autosomal dominant hearing loss (DFNA2) and neurological disorders, underscoring its physiological importance.

KCNQ4 antibodies are widely used in biomedical research to investigate the protein’s expression, localization, and functional interactions. They enable techniques such as Western blotting, immunohistochemistry, and immunofluorescence to visualize KCNQ4 distribution in tissues or cultured cells. These antibodies also aid in studying channelopathies, drug responses, and molecular mechanisms underlying diseases. For example, researchers employ them to explore how KCNQ4 dysfunction leads to hyperexcitability in neurons or hearing impairment.

Developed in various host species (e.g., rabbit, mouse), KCNQ4 antibodies are validated for specificity and sensitivity, often targeting epitopes in conserved regions like the C-terminus or pore domain. Their applications extend to screening therapeutic compounds targeting Kv7 channels for conditions like epilepsy or neuropathic pain. However, careful validation is essential to avoid cross-reactivity with homologous KCNQ subunits (e.g., KCNQ2. KCNQ3). Overall, KCNQ4 antibodies are indispensable for advancing our understanding of potassium channel biology and related pathologies.

       
關(guān)鍵字: KCNQ4抗體;KCNQ4;KCNQ4 Antibody;

公司簡(jiǎn)介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬(wàn)人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以?xún)?nèi)
主營(yíng)行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬(wàn)人民幣
  • 企業(yè)類(lèi)型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:生物試劑
  • 公司地址:青浦
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