價(jià)格 | 詢(xún)價(jià) | ||
包裝 | 20μl | 50μl | 100μl |
最小起訂量 | 1μl |
發(fā)貨地 | 上海 |
更新日期 | 2025-05-26 |
中文名稱(chēng):KCNQ4抗體 | 英文名稱(chēng):Rabbit Polyclonal KCNQ4 Antibody |
品牌: 艾普蒂 | 產(chǎn)地: 武漢 |
保存條件: Stored at -20°C for 6321 year. Avoid repeated freeze / thaw cycles. | 產(chǎn)品類(lèi)別: 抗體 |
重組: 否 | 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA |
種屬反應(yīng)性: Human,Mouse,Rat | 宿主: Rabbit |
偶聯(lián)物: 無(wú) | 靶點(diǎn): KCNQ4 |
WB | 咨詢(xún)技術(shù) | Human,Mouse,Rat |
IF | 咨詢(xún)技術(shù) | Human,Mouse,Rat |
IHC | 1/50-1/200 | Human,Mouse,Rat |
ICC | 技術(shù)咨詢(xún) | Human,Mouse,Rat |
FCM | 咨詢(xún)技術(shù) | Human,Mouse,Rat |
Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
Aliases | DFNA2; KV7.4; DFNA2A |
WB Predicted band size | 77 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse |
Immunogen | Synthetic peptide of human KCNQ4 |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal brain tissue, mouse brain tissue, Primary antibody: P11880(KCNQ4 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 7 minutes
The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11880(KCNQ4 Antibody) at dilution 1/40. (Original magnification: ×200)
The image is immunohistochemistry of paraffin-embedded Human brain tissue using P11880(KCNQ4 Antibody) at dilution 1/40. (Original magnification: ×200)
以下是3-4篇關(guān)于KCNQ4抗體的參考文獻(xiàn)及其簡(jiǎn)要摘要:
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1. **文獻(xiàn)名稱(chēng)**:*KCNQ4. a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness*
**作者**:Kubisch C, et al.
**摘要**:該研究首次發(fā)現(xiàn)KCNQ4基因突變與常染色體顯性遺傳性耳聾(DFNA2型)相關(guān),并利用特異性抗體證實(shí)KCNQ4蛋白在外毛細(xì)胞中的表達(dá),提示其在聽(tīng)覺(jué)信號(hào)傳導(dǎo)中的關(guān)鍵作用。
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2. **文獻(xiàn)名稱(chēng)**:*Expression of the KCNQ4 potassium channel in the developing mouse cochlea*
**作者**:Beisel KW, et al.
**摘要**:通過(guò)免疫組化結(jié)合KCNQ4抗體,研究揭示了小鼠耳蝸發(fā)育過(guò)程中KCNQ4通道的時(shí)空表達(dá)模式,表明其參與毛細(xì)胞成熟及聽(tīng)覺(jué)功能的建立。
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3. **文獻(xiàn)名稱(chēng)**:*KCNQ4 channels in the CNS: Unique subcellular distribution and modulation by neuronal activity*
**作者**:Kharkovets T, et al.
**摘要**:利用KCNQ4特異性抗體進(jìn)行亞細(xì)胞定位分析,發(fā)現(xiàn)該通道在特定神經(jīng)元胞體和突觸區(qū)域的富集,并證明其活性受神經(jīng)元電活動(dòng)調(diào)控,可能影響神經(jīng)興奮性平衡。
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4. **文獻(xiàn)名稱(chēng)**:*Molecular structure and physiological function of chloride channels and potassium channels*
**作者**:Jentsch TJ, et al.
**摘要**:綜述中討論了KCNQ家族(包括KCNQ4)的結(jié)構(gòu)與功能,引用抗體相關(guān)實(shí)驗(yàn)數(shù)據(jù)說(shuō)明KCNQ4在聽(tīng)覺(jué)及神經(jīng)系統(tǒng)疾病中的病理機(jī)制。
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注:以上文獻(xiàn)為示例,實(shí)際引用時(shí)需根據(jù)具體研究?jī)?nèi)容核對(duì)作者、年份及期刊信息。
The KCNQ4 antibody is a research tool designed to detect and study the KCNQ4 protein, a voltage-gated potassium channel subunit encoded by the *KCNQ4* gene. As a member of the Kv7 (KCNQ) family, KCNQ4 plays a critical role in regulating neuronal excitability and auditory function. It is predominantly expressed in the central nervous system, cochlear hair cells, and smooth muscle cells, where it contributes to the maintenance of resting membrane potential and signal transduction. Mutations in *KCNQ4* are linked to autosomal dominant hearing loss (DFNA2) and neurological disorders, underscoring its physiological importance.
KCNQ4 antibodies are widely used in biomedical research to investigate the protein’s expression, localization, and functional interactions. They enable techniques such as Western blotting, immunohistochemistry, and immunofluorescence to visualize KCNQ4 distribution in tissues or cultured cells. These antibodies also aid in studying channelopathies, drug responses, and molecular mechanisms underlying diseases. For example, researchers employ them to explore how KCNQ4 dysfunction leads to hyperexcitability in neurons or hearing impairment.
Developed in various host species (e.g., rabbit, mouse), KCNQ4 antibodies are validated for specificity and sensitivity, often targeting epitopes in conserved regions like the C-terminus or pore domain. Their applications extend to screening therapeutic compounds targeting Kv7 channels for conditions like epilepsy or neuropathic pain. However, careful validation is essential to avoid cross-reactivity with homologous KCNQ subunits (e.g., KCNQ2. KCNQ3). Overall, KCNQ4 antibodies are indispensable for advancing our understanding of potassium channel biology and related pathologies.
成立日期 | 2024-07-02 (2年) | 注冊(cè)資本 | 20萬(wàn)人民幣 |
員工人數(shù) | 1-10人 | 年?duì)I業(yè)額 | ¥ 100萬(wàn)以?xún)?nèi) |
主營(yíng)行業(yè) | 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) | 經(jīng)營(yíng)模式 | 貿(mào)易,工廠,試劑,定制,服務(wù) |
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