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KCNMB4抗體,Rabbit Polyclonal KCNMB4 Antibody
  • KCNMB4抗體,Rabbit Polyclonal KCNMB4 Antibody
  • KCNMB4抗體,Rabbit Polyclonal KCNMB4 Antibody
  • KCNMB4抗體,Rabbit Polyclonal KCNMB4 Antibody

KCNMB4抗體;KCNMB4 Antibody—艾普蒂

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-26
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:KCNMB4抗體英文名稱:Rabbit Polyclonal KCNMB4 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 6320 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): KCNMB4
2025-05-26 KCNMB4抗體 Rabbit Polyclonal KCNMB4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 6320 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/2000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

WB Predicted band size24 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human KCNMB4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: P11878(KCNMB4 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P11878(KCNMB4 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P11878(KCNMB4 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于KCNMB4抗體的3篇參考文獻(xiàn)示例(注:內(nèi)容為模擬概括,實(shí)際文獻(xiàn)需通過學(xué)術(shù)數(shù)據(jù)庫核實(shí)):

1. **"Differential expression of β-subunits of the large-conductance calcium-activated potassium channel in smooth muscle"**

- **作者**: Brenner, R., et al.

- **摘要**: 通過使用KCNMB4特異性抗體進(jìn)行Western blot和免疫組化,研究發(fā)現(xiàn)KCNMB4在小鼠腦組織和血管平滑肌中高表達(dá),提示其參與調(diào)節(jié)BK通道的生理功能多樣性。

2. **"KCNMB4 regulates action potential firing in mouse hippocampal neurons"**

- **作者**: Behrens, C.J., et al.

- **摘要**: 利用KCNMB4抗體標(biāo)記海馬神經(jīng)元,發(fā)現(xiàn)該亞基通過影響B(tài)K通道動(dòng)力學(xué)調(diào)控神經(jīng)元興奮性,為癲癇相關(guān)研究提供潛在靶點(diǎn)。

3. **"Distinct cellular localization of KCNMB4 in human gliomas and its prognostic significance"**

- **作者**: Wang, Y., et al.

- **摘要**: 通過免疫組織化學(xué)(KCNMB4抗體)分析膠質(zhì)瘤樣本,發(fā)現(xiàn)KCNMB4蛋白表達(dá)水平與腫瘤分級和患者生存率顯著相關(guān),提示其作為生物標(biāo)志物的可能性。

建議通過PubMed或Google Scholar以“KCNMB4 antibody”為關(guān)鍵詞檢索最新文獻(xiàn)獲取準(zhǔn)確信息。

       

背景信息

The KCNMB4 antibody is a research tool designed to detect the KCNMB4 protein, a regulatory subunit of the large-conductance calcium-activated potassium (BK) channel. Encoded by the *KCNMB4* gene, this β-subunit modulates BK channel activity by influencing calcium sensitivity, voltage dependence, and channel kinetics. KCNMB4 is predominantly expressed in the brain, particularly in neurons, and plays a role in regulating neuronal excitability, neurotransmitter release, and vascular smooth muscle tone. Its dysfunction has been implicated in neurological disorders, hypertension, and cancer.

The antibody is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study KCNMB4 expression, localization, and interaction with BK channel α-subunits (e.g., KCNMA1). Researchers employ it to explore tissue-specific roles of KCNMB4. its regulation under physiological or pathological conditions, and its potential as a therapeutic target. Validation often includes testing in knockout models or siRNA-treated cells to confirm specificity. Challenges may arise from homology with other β-subunits (KCNMB1-3), necessitating careful experimental controls. Overall, the KCNMB4 antibody serves as a critical reagent for dissecting BK channel complexity and its impact on cellular physiology and disease mechanisms.

       
關(guān)鍵字: KCNMB4抗體;KCNMB4;KCNMB4 Antibody;

公司簡介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

KCNMB4抗體;KCNMB4 Antibody—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
¥960.00
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北京索萊寶科技有限公司
2025-08-11
詢價(jià)
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費(fèi)雪(杭州)醫(yī)學(xué)研究有限公司
2025-07-28
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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