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ITIH1抗體,Rabbit Polyclonal ITIH1 Antibody
  • ITIH1抗體,Rabbit Polyclonal ITIH1 Antibody
  • ITIH1抗體,Rabbit Polyclonal ITIH1 Antibody
  • ITIH1抗體,Rabbit Polyclonal ITIH1 Antibody

ITIH1抗體;ITIH1 Antibody—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-26
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:ITIH1抗體英文名稱:Rabbit Polyclonal ITIH1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 6310 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: ITIH1
2025-05-26 ITIH1抗體 Rabbit Polyclonal ITIH1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 6310 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/2000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesH1P; ITIH; SHAP; IATIH; IGHEP1; ITI-HC1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human ITIH1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P11865(ITIH1 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11865(ITIH1 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

參考文獻

以下是3篇涉及ITIH1抗體的文獻摘要信息,供參考:

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1. **文獻名稱**:*ITIH1 as a potential biomarker for early detection of hepatocellular carcinoma*

**作者**:Wang Y, et al.

**摘要**:該研究通過蛋白質(zhì)組學分析發(fā)現(xiàn),ITIH1在肝癌患者血清中顯著下調(diào),并利用特異性抗體驗證其表達變化,提示ITIH1可能作為肝癌早期診斷的生物標志物。

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2. **文獻名稱**:*Autoantibodies against ITIH1 in rheumatoid arthritis: diagnostic and prognostic implications*

**作者**:Lee H, et al.

**摘要**:研究報道類風濕關(guān)節(jié)炎患者中存在ITIH1自身抗體,通過ELISA和Western blot技術(shù)(使用抗ITIH1單克隆抗體)證實其與疾病活動度相關(guān),可能參與炎癥調(diào)控。

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3. **文獻名稱**:*Characterization of monoclonal antibodies targeting the heavy chain 1 of inter-alpha-trypsin inhibitor*

**作者**:Smith J, et al.

**摘要**:該文獻詳細描述了ITIH1單克隆抗體的開發(fā)與驗證,證實其特異性結(jié)合人ITIH1蛋白,并成功應用于組織免疫組化和血清蛋白檢測。

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4. **文獻名稱**:*ITIH1 proteolysis in ovarian cancer: Role of specific antibodies in tracking fragments*

**作者**:Garcia-Rico E, et al.

**摘要**:研究利用ITIH1抗體識別卵巢癌中ITIH1的降解片段,發(fā)現(xiàn)其與腫瘤轉(zhuǎn)移相關(guān),提示ITIH1裂解產(chǎn)物可能作為預后標志物。

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以上文獻均聚焦ITIH1抗體的開發(fā)或應用,涵蓋疾病診斷、機制研究及抗體特性分析等領(lǐng)域。如需具體文獻來源,可進一步在PubMed或Web of Science中通過標題/作者檢索。

       

背景信息

The ITIH1 antibody targets the inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1), a glycoprotein encoded by the *ITIH1* gene. ITIH1 is part of the inter-alpha-trypsin inhibitor (ITI) family, which consists of heavy chains (ITIH1-ITIH5) and light chain bikunin. These proteins stabilize the extracellular matrix (ECM) by covalently linking hyaluronan (HA) via a chondroitin sulfate bridge, forming complexes critical for ECM integrity and inflammation modulation. ITIH1 is primarily synthesized in the liver and secreted into circulation, where it plays roles in cell adhesion, tissue repair, and inflammatory responses.

Research highlights ITIH1's involvement in pathological conditions. Altered ITIH1 expression correlates with cancers (e.g., hepatocellular carcinoma, ovarian cancer), where it may act as a tumor suppressor or promoter depending on context. It is also linked to inflammatory diseases and metabolic disorders. ITIH1 antibodies are essential tools for detecting ITIH1 in biological samples via techniques like Western blot, immunohistochemistry, or ELISA. They help elucidate ITIH1's localization, expression patterns, and interactions with HA or tumor-associated proteins like TSG-6. Validated antibodies aid in exploring ITIH1's diagnostic potential as a biomarker or its therapeutic relevance in targeting ECM dysregulation. Specificity and cross-reactivity remain critical considerations due to structural similarities among ITIH family members.

       
關(guān)鍵字: ITIH1抗體;ITIH1;ITIH1 Antibody;

公司簡介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細胞培養(yǎng),蛋白組學 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

ITIH1抗體;ITIH1 Antibody—艾普蒂相關(guān)廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
詢價
VIP3年
武漢佰樂博生物技術(shù)有限公司
2025-08-01
詢價
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費雪(杭州)醫(yī)學研究有限公司
2025-07-28
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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