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TDP2抗體,Rabbit Polyclonal TDP2 Antibody
  • TDP2抗體,Rabbit Polyclonal TDP2 Antibody
  • TDP2抗體,Rabbit Polyclonal TDP2 Antibody
  • TDP2抗體,Rabbit Polyclonal TDP2 Antibody

TDP2抗體;TDP2 Antibody—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-26
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:TDP2抗體英文名稱:Rabbit Polyclonal TDP2 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 6241 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: TDP2
2025-05-26 TDP2抗體 Rabbit Polyclonal TDP2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 6241 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/300 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesEAP2; AD022; EAPII; TTRAP; hTDP2; dJ30M3.3
WB Predicted band size41 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human TDP2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse small intestines tissue lysate, Primary antibody: P11748(TDP2 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 90 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P11748(TDP2 Antibody) at dilution 1/75. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11748(TDP2 Antibody) at dilution 1/75. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于TDP2抗體的3篇參考文獻(xiàn),包含文獻(xiàn)名稱、作者及簡要摘要內(nèi)容:

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1. **文獻(xiàn)名稱**:*TDP2 promotes repair of topoisomerase I-mediated DNA damage in neurons*

**作者**:Katyal S, et al.

**摘要**:該研究通過TDP2特異性抗體檢測,揭示了TDP2在神經(jīng)元中修復(fù)拓?fù)洚悩?gòu)酶I誘導(dǎo)的DNA斷裂的關(guān)鍵作用,并發(fā)現(xiàn)其缺失會導(dǎo)致神經(jīng)退行性病變的累積。

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2. **文獻(xiàn)名稱**:*TDP2 inhibition potentiates cancer chemotherapy by inducing lethal DNA breaks*

**作者**:Huang SY, et al.

**摘要**:利用TDP2抗體進(jìn)行蛋白表達(dá)分析,研究發(fā)現(xiàn)抑制TDP2可增強(qiáng)化療藥物(如依托泊苷)的療效,因其阻礙了癌細(xì)胞修復(fù)DNA損傷的能力,為癌癥治療提供新策略。

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3. **文獻(xiàn)名稱**:*A monoclonal antibody against human TDP2 reveals its nuclear localization and enzymatic activity*

**作者**:Cortes Ledesma F, et al.

**摘要**:本研究開發(fā)了一種特異性識別人類TDP2的單克隆抗體,驗證了TDP2的核定位及其對5'-磷酸酪氨酸DNA鍵的水解活性,為后續(xù)功能研究提供工具。

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4. **文獻(xiàn)名稱**:*TDP2 deficiency in zebrafish embryos leads to neurodevelopmental defects*

**作者**:Almeida KH, et al.

**摘要**:通過免疫組化(TDP2抗體標(biāo)記)和基因編輯技術(shù),發(fā)現(xiàn)斑馬魚中TDP2缺失導(dǎo)致神經(jīng)發(fā)育異常,強(qiáng)調(diào)其在維持基因組穩(wěn)定性中的進(jìn)化保守性。

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以上文獻(xiàn)涵蓋了TDP2抗體在神經(jīng)科學(xué)、癌癥治療、工具開發(fā)及發(fā)育生物學(xué)中的應(yīng)用場景。

       

背景信息

**Background of TDP2 Antibody**

Tyrosyl-DNA phosphodiesterase 2 (TDP2), also known as TRAF and TNF receptor-associated protein (TTRAP), is a multifunctional enzyme critical for repairing DNA damage caused by topoisomerase II (TOP2) activity. TDP2 specifically cleaves 5'-phosphotyrosine bonds left on DNA after TOP2-mediated cleavage, resolving abortive TOP2-DNA complexes and preventing genomic instability. This repair mechanism is vital for maintaining DNA integrity, particularly in response to chemotherapeutic agents like etoposide, which stabilize TOP2-DNA cleavage intermediates.

Structurally, TDP2 contains an N-terminal catalytic domain with a phosphodiesterase fold and a C-terminal region involved in protein-protein interactions. Its role extends beyond DNA repair, with studies implicating TDP2 in transcriptional regulation, innate immune signaling, and neurodegenerative diseases. For instance, TDP2 mutations are linked to spinocerebellar ataxia and amyotrophic lateral sclerosis (ALS), highlighting its neuroprotective functions.

TDP2 antibodies are essential tools for studying the protein's expression, localization, and interactions. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research utilizing TDP2 antibodies has advanced understanding of its dual roles in genome stability and disease pathogenesis, making it a potential therapeutic target for cancer and neurodegenerative disorders. Ongoing studies aim to develop TDP2 inhibitors to sensitize cancer cells to TOP2-targeting drugs or modulate its activity in neurological conditions.

       
關(guān)鍵字: TDP2抗體;TDP2;TDP2 Antibody;

公司簡介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

TDP2抗體;TDP2 Antibody—艾普蒂相關(guān)廠家報價

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