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CD5L抗體,Rabbit Polyclonal CD5L Antibody
  • CD5L抗體,Rabbit Polyclonal CD5L Antibody
  • CD5L抗體,Rabbit Polyclonal CD5L Antibody
  • CD5L抗體,Rabbit Polyclonal CD5L Antibody

CD5L抗體;CD5L Antibody—艾普蒂

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-26
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產(chǎn)品詳情

中文名稱:CD5L抗體英文名稱:Rabbit Polyclonal CD5L Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 6186 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): CD5L
2025-05-26 CD5L抗體 Rabbit Polyclonal CD5L Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 6186 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/1000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesAIM; API6; PRO229; Spalpha; SP-ALPHA
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human CD5L
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human Lymphoma tissue using P11648(CD5L Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11648(CD5L Antibody) at dilution 1/40. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于CD5L抗體的示例性參考文獻(xiàn)(注:內(nèi)容為模擬示例,非真實(shí)文獻(xiàn)):

1. **標(biāo)題**:*CD5L Antibody Attenuates Liver Fibrosis via Modulating Macrophage Polarization*

**作者**:Zhang Y, et al.

**摘要**:研究利用抗CD5L抗體在小鼠肝纖維化模型中干預(yù),發(fā)現(xiàn)其通過抑制促炎性巨噬細(xì)胞活化,促進(jìn)M2型極化,顯著減少膠原沉積,提示CD5L抗體在纖維化疾病中的治療潛力。

2. **標(biāo)題**:*Therapeutic Targeting of CD5L in Rheumatoid Arthritis with Humanized Monoclonal Antibodies*

**作者**:Smith J, et al.

**摘要**:開發(fā)人源化抗CD5L單克隆抗體,在類風(fēng)濕性關(guān)節(jié)炎模型中驗(yàn)證其療效,結(jié)果顯示抗體通過阻斷CD5L與凋亡細(xì)胞結(jié)合,降低炎癥因子水平并緩解關(guān)節(jié)損傷。

3. **標(biāo)題**:*CD5L as a Biomarker in Metabolic Syndrome: Insights from Antibody-Based Detection*

**作者**:Lee H, et al.

**摘要**:通過抗CD5L抗體檢測(cè)血漿CD5L水平,發(fā)現(xiàn)其與肥胖患者的胰島素抵抗和脂肪組織炎癥呈正相關(guān),提示CD5L可作為代謝綜合征的潛在生物標(biāo)志物。

4. **標(biāo)題**:*Structural Basis of CD5L Recognition by Neutralizing Antibodies in Atherosclerosis*

**作者**:Garcia-Ruiz C, et al.

**摘要**:解析CD5L蛋白與中和抗體的復(fù)合物結(jié)構(gòu),揭示抗體通過阻斷CD5L與氧化低密度脂蛋白結(jié)合,抑制動(dòng)脈粥樣硬化斑塊形成,為抗體藥物開發(fā)提供依據(jù)。

(注:以上文獻(xiàn)信息為模擬生成,實(shí)際引用時(shí)需以真實(shí)數(shù)據(jù)庫檢索結(jié)果為準(zhǔn)。)

       

背景信息

CD5L (CD5 Antigen-Like), also known as APRIL or CD5L, is a secreted glycoprotein belonging to the scavenger receptor cysteine-rich (SRCR) superfamily. Primarily expressed in immune cells like macrophages, dendritic cells, and specific lymphocyte subsets, it plays regulatory roles in inflammation, apoptosis, and lipid metabolism. Its structure includes conserved SRCR domains that mediate interactions with cell surface receptors such as CD5 and TLT-1. influencing immune signaling pathways.

CD5L antibodies are critical tools for studying its dual roles in disease contexts. In autoimmune disorders (e.g., rheumatoid arthritis), CD5L may suppress excessive inflammation by modulating macrophage activity. Conversely, in chronic infections or cancers, it might promote immune evasion by altering cytokine profiles in the tumor microenvironment. Its involvement in lipid homeostasis also links CD5L to metabolic diseases; elevated levels correlate with atherosclerosis progression through lipid-laden macrophage formation.

Research applications of CD5L antibodies include immunohistochemistry, flow cytometry, and functional blocking assays to dissect its mechanisms. Therapeutic potential is being explored, with antibody-based strategies aiming to either neutralize CD5L in pro-inflammatory conditions or enhance its activity in metabolic syndromes. Despite progress, its context-dependent functions require careful targeting to avoid paradoxical effects. Ongoing studies focus on tissue-specific expression patterns and receptor cross-talk to refine clinical applications.

       
關(guān)鍵字: CD5L抗體;CD5L;CD5L Antibody;

公司簡(jiǎn)介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

CD5L抗體;CD5L Antibody—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
¥3384
VIP4年
上海博爾森生物科技有限公司
2025-08-01
¥2304
VIP6年
上海澤葉生物科技有限公司
2025-08-01
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