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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     Western blot analysis of ABCD1 / ALD in HepG2  cell lysate.    

  
  

ABCD1 (ATP-binding cassette sub-family D member 1), also known as ALDP, is a peroxisomal membrane protein encoded by the *ABCD1* gene. It plays a critical role in transporting very long-chain fatty acids (VLCFAs) into peroxisomes for β-oxidation. Mutations in *ABCD1* cause X-linked adrenoleukodystrophy (ALD), a neurodegenerative disorder characterized by the accumulation of VLCFAs, leading to demyelination, adrenal insufficiency, and progressive neurological decline. ALD manifests in varied forms, including cerebral ALD in children and adrenomyeloneuropathy in adults.

ABCD1/ALD antibodies are essential tools for studying the protein's expression, localization, and function. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect ABCD1 in tissues or cell lines. They help researchers assess protein levels in ALD patients, aiding in diagnostic confirmation and mechanistic studies. Some antibodies target specific epitopes, enabling differentiation between wild-type and mutant forms. Additionally, they are employed in preclinical research to evaluate gene therapy or pharmacological interventions aimed at restoring ABCD1 function. Commercially available antibodies are often validated in human, mouse, or rat samples, with cross-reactivity depending on species homology. Reliable ABCD1 antibodies are crucial for advancing ALD research, understanding peroxisomal biology, and developing targeted therapies for this currently incurable disease.