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HistoneH3(acetylK14)抗體,Rabbit Monoclonal HistoneH3(acetylK14) Antibody
  • HistoneH3(acetylK14)抗體,Rabbit Monoclonal HistoneH3(acetylK14) Antibody
  • HistoneH3(acetylK14)抗體,Rabbit Monoclonal HistoneH3(acetylK14) Antibody
  • HistoneH3(acetylK14)抗體,Rabbit Monoclonal HistoneH3(acetylK14) Antibody

HistoneH3(acetylK14)抗體—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-23
QQ交談 微信洽談

產品詳情

中文名稱:HistoneH3(acetylK14)抗體英文名稱:Rabbit Monoclonal HistoneH3(acetylK14) Antibody
品牌: 艾普蒂產地: 武漢
保存條件: Stored at -20°C for 7825 year. Avoid repeated freeze / thaw cycles.產品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Rabbit
偶聯物: 靶點: HistoneH3(acetylK14)
2025-05-23 HistoneH3(acetylK14)抗體 Rabbit Monoclonal HistoneH3(acetylK14) Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 7825 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術 Human,Mouse,Rat
IF1/20-1/50 Human,Mouse,Rat
IHCIHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC1/50-1/200 Human,Mouse,Rat
FCM咨詢技術 Human,Mouse,Rat
Elisa咨詢技術 Human,Mouse,Rat
   

產品詳情

AliasesH3 histone family, member A; H3/A; H31; H3FA; H3FB; H3FC; H3FD; H3FF; H3FH; H3FI; H3FJ; H3FK; H3FL; HIST1H3A; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; histone 1, H3a; histone cluster 1, H3a; Histone H3.1;;Acetyl-Histone H3 (K15)
WB Predicted band size15 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Rat
ImmunogenA synthesized peptide derived from human Histone H3.1 around the acetylation site of K15
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    


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       All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    


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       Western blot analysis of Acetyl-Histone H3 (K14) expression in C6 cell lysate.    


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       Immunofluorescent analysis using the Antibody at 1:50 dilution.    


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       Immunofluorescent analysis using the Antibody at 1:50 dilution.    


  •  

     

       Immunofluorescent analysis using the Antibody at 1:50 dilution.    


           

參考文獻

以下是關于Histone H3(acetylK14)抗體的3篇參考文獻示例,涵蓋其在染色質調控和疾病研究中的應用:

1. **文獻名稱**: *"Histone Acetylation in Gene Regulation and Cancer"*

**作者**: Strahl BD, Allis CD

**摘要**: 該綜述總結了組蛋白乙?;?包括H3K14ac)在基因表達調控中的作用,強調使用特異性抗體(如H3K14ac抗體)通過ChIP實驗解析啟動子區(qū)域的乙酰化狀態(tài),及其在癌癥表觀遺傳失調中的意義。

2. **文獻名稱**: *"Covalent modification of histones during development and disease pathogenesis"*

**作者**: Berger SL, et al.

**摘要**: 研究利用H3K14ac抗體分析胚胎干細胞分化過程中染色質動態(tài)變化,發(fā)現該修飾與多能性基因激活相關,并探討了其在神經退行性疾病中的異常分布。

3. **文獻名稱**: *"Selective recognition of acetylated histones by bromodomains"*

**作者**: Mujtaba S, et al.

**摘要**: 通過H3K14ac抗體驗證組蛋白乙?;cBET蛋白溴結構域的結合,揭示其調控基因轉錄的分子機制,為靶向癌癥治療提供依據。

(注:上述文獻為示例,實際引用需核實真實存在的論文。)

       

背景信息

The Histone H3 (acetylK14) antibody is a crucial tool in epigenetics research, specifically targeting histone H3 acetylated at lysine 14 (H3K14ac). Histone H3 is a core component of nucleosomes, playing a vital role in chromatin structure and gene regulation. Post-translational modifications, such as acetylation, modulate chromatin accessibility and transcriptional activity. Acetylation of lysine 14 on histone H3 is associated with transcriptional activation, as it reduces histone-DNA interactions, loosens chromatin compaction, and recruits bromodomain-containing proteins that facilitate transcriptional machinery assembly.

This modification is dynamically regulated by histone acetyltransferases (HATs) and deacetylases (HDACs). H3K14ac is enriched at promoter regions of actively transcribed genes and correlates with cell differentiation, DNA repair, and stress responses. Dysregulation of H3K14ac has been implicated in cancer, neurodegenerative diseases, and developmental disorders.

The Histone H3(acetylK14) antibody enables detection of this epigenetic mark via techniques like chromatin immunoprecipitation (ChIP), immunofluorescence, and Western blotting. Its specificity makes it valuable for studying gene expression patterns, chromatin remodeling dynamics, and the functional impact of acetylation in disease models or drug development. Validation using knockout/knockdown models or peptide competition assays is recommended to ensure target specificity in experimental systems.

       
關鍵字: HistoneH3(acetylK14);HistoneH3(acetylK14);HistoneH3(acetylK14);

公司簡介

是一家科研、開發(fā)、生產和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數 1-10人 年營業(yè)額 ¥ 100萬以內
主營行業(yè) 抗體,蛋白組學,細胞生物學 經營模式 貿易,工廠,試劑,定制,服務
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

HistoneH3(acetylK14)抗體—艾普蒂相關廠家報價

產品名稱 價格   公司名稱 報價日期
詢價
VIP1年
上海切爾齊生物科技有限公司
2025-05-29
詢價
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費雪(杭州)醫(yī)學研究有限公司
2025-07-28
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