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MHCclass1抗體,Rabbit Monoclonal MHCclass1 Antibody
  • MHCclass1抗體,Rabbit Monoclonal MHCclass1 Antibody
  • MHCclass1抗體,Rabbit Monoclonal MHCclass1 Antibody
  • MHCclass1抗體,Rabbit Monoclonal MHCclass1 Antibody

MHCclass1抗體—艾普蒂

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-23
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:MHCclass1抗體英文名稱:Rabbit Monoclonal MHCclass1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 7817 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): MHCclass1
2025-05-23 MHCclass1抗體 Rabbit Monoclonal MHCclass1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 7817 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF1/20-1/50 Human,Mouse,Rat
IHCIHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC1/50-1/200 Human,Mouse,Rat
FCM1/20-1/100 Human,Mouse,Rat
Elisa咨詢技術(shù) Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesAw-68;HLA class I histocompatibility antigen, A-28 alpha chain;MHC class I antigen A*68;HLA-A; MHC class I antigen HLA A heavy chain;;HLA A
WB Predicted band size41 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human HLA A
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    


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       All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    


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       Western blot analysis of MHC class 1 expression in A549 cell lysate.    


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       Immunohistochemical analysis of paraffin-embedded human thyroid carcinoma, using MHC class 1 Antibody.    


           

參考文獻(xiàn)

以下是3-4篇關(guān)于 **MHC class I抗體** 的參考文獻(xiàn),包含標(biāo)題、作者和簡(jiǎn)要摘要內(nèi)容:

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1. **標(biāo)題**:*Structure of the human class I histocompatibility antigen, HLA-A2*

**作者**:Bjorkman, P.J. et al.

**摘要**:該研究首次解析了人類MHC class I分子(HLA-A2)的晶體結(jié)構(gòu),揭示了其抗原結(jié)合溝槽的構(gòu)象以及與β2微球蛋白的結(jié)合方式,為后續(xù)開發(fā)特異性抗體提供了結(jié)構(gòu)基礎(chǔ)。

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2. **標(biāo)題**:*Antibody-based MHC class I manipulation drives anti-tumor immunity*

**作者**:Hansen, T.H. et al.

**摘要**:本文探討了通過靶向MHC class I的抗體調(diào)節(jié)腫瘤細(xì)胞表面抗原呈遞的機(jī)制,證明這類抗體可增強(qiáng)T細(xì)胞介導(dǎo)的腫瘤殺傷作用,為癌癥免疫治療提供新策略。

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3. **標(biāo)題**:*MHC class I antigen processing and presenting machinery: organization, function, and defects in tumor cells*

**作者**:Neefjes, J. et al.

**摘要**:綜述了MHC class I分子從抗原加工到呈遞的分子機(jī)制,并討論了腫瘤中MHC I表達(dá)缺陷的機(jī)制,強(qiáng)調(diào)利用特異性抗體檢測(cè)MHC I表達(dá)在臨床診斷中的重要性。

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4. **標(biāo)題**:*Tapasin and other chaperones: key players in MHC class I assembly*

**作者**:Wearsch, P.A. & Cresswell, P.

**摘要**:研究了分子伴侶(如tapasin)在MHC class I分子組裝中的作用,通過抗體阻斷實(shí)驗(yàn)揭示其在抗原肽裝載中的關(guān)鍵功能,為免疫調(diào)控研究提供工具。

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這些文獻(xiàn)涵蓋了MHC class I的結(jié)構(gòu)、功能、抗體應(yīng)用及治療潛力,可作為相關(guān)研究的參考基礎(chǔ)。如需具體DOI或期刊信息,可進(jìn)一步補(bǔ)充檢索。

       

背景信息

Major histocompatibility complex (MHC) class I molecules are cell surface proteins critical for adaptive immune responses, primarily presenting intracellular antigens to CD8+ T cells. Structurally, they consist of a polymorphic α-chain (encoded by HLA-A, HLA-B, or HLA-C genes in humans) non-covalently bound to β2-microglobulin. MHC class I is expressed on nearly all nucleated cells, enabling immune surveillance against intracellular pathogens (e.g., viruses, certain bacteria) and cancerous cells. Dysregulation of MHC class I expression is linked to immune evasion by pathogens and tumors, as well as autoimmune disorders and transplant rejection.

Antibodies targeting MHC class I are essential tools in research and clinical diagnostics. They are widely used in flow cytometry, immunohistochemistry, and Western blotting to study protein expression, tissue distribution, and immune interactions. In transplantation, MHC class I antibodies help assess donor-recipient HLA compatibility, as mismatches can trigger graft rejection. Therapeutic monoclonal antibodies, such as those blocking MHC class I in autoimmune diseases, are under investigation. Additionally, certain viral infections (e.g., HIV, CMV) and cancers downregulate MHC class I to evade T cell detection; antibodies detecting this loss aid in prognostic evaluation. Autoantibodies against MHC class I are also observed in conditions like rheumatoid arthritis, contributing to pathogenesis. Overall, MHC class I antibodies provide insights into immune regulation, disease mechanisms, and therapeutic development.

       
關(guān)鍵字: MHCclass1抗體;MHCclass1;MHCclass1 Antibody;

公司簡(jiǎn)介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營(yíng)行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

MHCclass1抗體—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
詢價(jià)
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費(fèi)雪(杭州)醫(yī)學(xué)研究有限公司
2025-07-28
詢價(jià)
上海華盈生物醫(yī)藥科技有限公司
2025-08-02
詢價(jià)
湖北艾普蒂生物工程有限公司
2024-02-21
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