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     Western blot analysis using HNRNPK mouse mAb against  HeLa lysate    

  
  

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     Lane 1: HeLa lysate;  Lane 2: HNRNPK immunoprecipitated from HeLa lysate by P16318;  Lane 3: The same as Lane 2 but use IgG isotype control antibody;Result: P16318 can immunoprecipitate HNRNPK;    

  
  

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     IHC-P analysis of kidney tissue by HNRNPK antibody (P16318) IHC-P was performed using sections of the formalin-fixed paraffin-embedded kidney tissue;Result: Cells in glomeruli and tubules are positively stained at the nuclei.    

  
  

The heterogeneous nuclear ribonucleoprotein K (HNRNPK) is a multifunctional RNA-binding protein involved in transcriptional and post-transcriptional regulation of gene expression. It belongs to the hnRNP family and plays critical roles in RNA processing, DNA repair, chromatin remodeling, and cellular stress responses. HNRNPK interacts with nucleic acids (RNA/DNA) and proteins through its three K-homology (KH) domains, acting as a molecular scaffold to integrate signaling pathways. Its functions span mRNA stabilization, splicing, translation, and epigenetic regulation, impacting cell proliferation, differentiation, and apoptosis.

HNRNPK antibodies are essential tools for studying its expression, localization, and interactions in both physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry. Dysregulation of HNRNPK is linked to cancers (e.g., leukemia, breast, and liver cancer), neurological disorders, and developmental defects, making its detection crucial for understanding disease mechanisms. Research using HNRNPK antibodies has highlighted its role in oncogenic signaling, viral replication, and stress granule formation, underscoring its potential as a therapeutic or diagnostic target. Validation of antibody specificity remains critical due to structural similarities among KH domain proteins.